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CA1 pyramidal neuron dendritic spine with plasticity (O`Donnell et al. 2011)
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Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule. The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.
O'Donnell C, Nolan MF, van Rossum MCW (2011) Dendritic spine dynamics regulate the long-term stability of synaptic plasticity.
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Hippocampus CA1 pyramidal cell;
O`Donnell, Cian [cian AT salk.edu];
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Hippocampus CA1 pyramidal cell
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