CA1 pyramidal neuron dendritic spine with plasticity (O`Donnell et al. 2011)

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Accession:144463
Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule. The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.
Reference:
1 . O`Donnell C, Nolan MF, van Rossum MCW (2011) Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. J Neurosci 31:16142-56 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Cav3.1 CACNA1G; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.1 CACNA1A;
Transmitter(s): Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Synaptic Plasticity; Calcium dynamics;
Implementer(s): O`Donnell, Cian [cian AT salk.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; Glutamate;
 
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ODonelletal_spinemodel
readme.txt
spinemodel_fig6.m
spineodes.m
                            
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