Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
ModelDB related resources
Computational neuroscience ecosystem
Models in mercurial repository
CA1 pyramidal neuron dendritic spine with plasticity (O`Donnell et al. 2011)
Download zip file
Help downloading and running models
Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule. The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.
O`Donnell C, Nolan MF, van Rossum MCW (2011) Dendritic spine dynamics regulate the long-term stability of synaptic plasticity.
(Click on a link to find other models with that property)
Hippocampus CA1 pyramidal cell;
O`Donnell, Cian [cian AT salk.edu];
for information about:
Hippocampus CA1 pyramidal cell
File not selected
<- Select file from this column.
Loading data, please wait...
Questions, comments, problems? Email the
How to cite ModelDB
© This site is Copyright 2018 Shepherd Lab, Yale University