Nodes of Ranvier with left-shifted Nav channels (Boucher et al. 2012)

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Accession:144481
The two programs CLSRanvier.f and propagation.f simulate the excitability of a myelinated axon with injured nodes of Ranvier. The injury is simulated as the Coupled Left Shift (CLS) of the activation(V) and inactivation(V) (availability) of a fraction of Nav channels.
Reference:
1 . Boucher PA, Joos B, Morris CE (2012) Coupled left-shift of Nav channels: modeling the Na(+)-loading and dysfunctional excitability of damaged axons J Comput Neurosci. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron; Hodgkin-Huxley neuron;
Channel(s): I Na,t; I K; I K,leak; Na/K pump; I Na, leak;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.6 SCN8A;
Transmitter(s):
Simulation Environment: FORTRAN;
Model Concept(s): Action Potential Initiation; Activity Patterns; Pathophysiology; Conduction failure; Sodium pump; Depolarization block; Homeostasis;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I K; I K,leak; Na/K pump; I Na, leak;
/
Boucher2012
Readme.txt
CLSRanvier.f
propagation.f
                            
Name of Model: Nodes of Ranvier with Left shifted Nav channels

Reference: Boucher PA, Joos B, Morris CE (2012) Coupled left-shift of
Nav channels: modeling the Na(+)-loading and dysfunctional
excitability of damaged axons J Comput Neurosci.

ModelDB Accession: 144481
These files were supplied by Dr. B. Joos.

The two programs CLSRanvier.f and propagation.f simulate the
excitability of a myelinated axon with injured nodes of Ranvier.  The
injury is simulated as the Coupled Left shift (CLS) of the activation
and inactivation of a fraction of Nav channels.

Program CLSRanvier.f

This program calculates the time evolution of the membrane potential
at a node of Ranvier with left-shifted Nav currents.

Program propagation.f

This program calculates the time evolution of the membrane potential
for a series of nodes of Ranvier connected by simple resistors,
representing the myelenated segments of axons.  The simulation is
carried 30 times (30 values of shift) for 6 different values of LS. No
stimulation current is used on the initial node, so spontaneous firing
of the nodes is studied.  A single node (node 5) has shifted channels.

Usage:

These programs are compatible with the linux gfortran compiler.  They
can be compiled with the commands

gfortran -o CLSRanvier CLSRanvier.f
gfortran -o propagation propagation.f

and then run with commands

./CLSRanvier
./propagation

On a 2.40GHz Intel Core 2 Duo P8600 (Dell laptop) it takes 15 seconds
to run CLSRanvier and 11 minutes to run propagation.

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