Nodes of Ranvier with left-shifted Nav channels (Boucher et al. 2012)

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Accession:144481
The two programs CLSRanvier.f and propagation.f simulate the excitability of a myelinated axon with injured nodes of Ranvier. The injury is simulated as the Coupled Left Shift (CLS) of the activation(V) and inactivation(V) (availability) of a fraction of Nav channels.
Reference:
1 . Boucher PA, Joos B, Morris CE (2012) Coupled left-shift of Nav channels: modeling the Na(+)-loading and dysfunctional excitability of damaged axons J Comput Neurosci. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron; Hodgkin-Huxley neuron;
Channel(s): I Na,t; I K; I K,leak; Na/K pump; I Na, leak;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.6 SCN8A;
Transmitter(s):
Simulation Environment: FORTRAN;
Model Concept(s): Action Potential Initiation; Activity Patterns; Pathophysiology; Conduction failure; Sodium pump; Depolarization block; Homeostasis;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I K; I K,leak; Na/K pump; I Na, leak;
 
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Boucher2012
                            
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