CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS Comput Biol 8:e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
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bpap
CA1_multi
morphology
old20100922cell2
apical-non-trunk-list.hoc *
apical-trunk-list.hoc *
axonpoirazi.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell-analysis.hoc
gabab-gabaa-uniform-ratio.hoc *
nmda-ampa-ratio.hoc *
oblique-paths.hoc *
old20100922cell2_top.hoc
old20100922cell2_topadj.hoc *
soma-list.hoc *
                            
// The NMDA conductance at each synapse in the cell is estimated as 
// a percent of the AMPA conductance. The ratio of NMDA/AMPA conductances
// for different cell regions are given by the following values.
// modified by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

SOMA_NMDA_AMPA_RATIO=0.6
AXON_NMDA_AMPA_RATIO=0.6
BASAL_NMDA_AMPA_RATIO=0.6
APICAL_TRUNK_NMDA_AMPA_RATIO=0.6
APICAL_NON_TRUNK_NMDA_AMPA_RATIO=2.5



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