CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS Comput Biol 8:e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
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bpap
CA1_multi
datastore
pars
plots
poirazi-nmda-car
tests
validation-plots
README.txt
ampa_forti.mod
cacum.mod
cad.mod *
cagk.mod
cal.mod
calH.mod
car.mod
car_mag.mod
cat.mod
d3.mod *
h.mod
hha_old.mod
hha2.mod
kadist.mod
kaprox.mod
kca.mod
km.mod
nap.mod
nmda_andr.mod
somacar.mod
binaverages.m
bpap-cell.hoc
bpap-data.hoc
bpap-dendburst.hoc
bpap-graphics.hoc
bpap-gui.hoc
bpap-gui.ses
bpap-pars.hoc
bpap-record.hoc
bpap-run.hoc
bpap-scaling.hoc
bpap-sims.hoc
bpap-sims-cell1.hoc
bpap-sims-cell2.hoc
bpap-sims-scaling.hoc
bpap-somainj.hoc
bpap-spiketrain.hoc
ca1_mrg_cell1.hoc
ca1_mrg_cell2.hoc
ca1_poirazi.hoc
ChannelBlocker.hoc
CrossingFinder.hoc
epspsizes.hoc
figure-example.R
figures.R
figures-common.R
FileUtils.hoc
FormatFile.hoc
ghk.inc
GraphUtils.hoc
Integrator.hoc
Makefile
mosinit.hoc
NmdaAmpaSpineSynStim.hoc
NmdaAmpaSynStim.hoc
ObjectClass.hoc
plotscalingresults_pergroup1.m
plotscalingresults5.m
PointProcessDistributor.hoc
ReferenceAxis.hoc
removezeros.m
RPlot.hoc
scaling_plots.m
Segment.hoc
SimpleSpine.hoc
Spine.hoc
TreePlot.hoc
TreePlotArray.hoc
triexpsyn.inc
units.inc
utils.hoc
validate-bpap.hoc
VarList.hoc
VCaGraph.hoc
                            
COMMENT

Forti etal's (1997) AMPA synapse with two decay time constants based on the 
exp2syn.mod mechanism from the NEURON distribution

The value of 0.002 for the fraction of Ca flowing at low membrane
potentials is derived from the measurements of Spruston &al (1995)

Forti & al. 1997 "Loose-patch recordings of single quanta at
  individual hippocampal synapses" Nature 388, 874-878

Spruston & al. 1995 "Dendritic glutamate receptor channels in rat
  hippocampal CA3 and CA1 neurons" J. Physiol. 482, 325-352

ENDCOMMENT

NEURON {
	  POINT_PROCESS AmpaSyn
	  RANGE  e, g, i, ica
	  NONSPECIFIC_CURRENT i
    USEION ca READ cai,cao WRITE ica
    GLOBAL total, taurise, taufast, tauslow, taurise_exp, taufast_exp, tauslow_exp, afast, aslow, normfac, T_exp, fracca
}

INCLUDE "units.inc"

PARAMETER {
	  taurise_exp =.2 (ms) <1e-9,1e9>       : rise
	  taufast_exp = 0.61 (ms) <1e-9,1e9>    : fast decay
	  tauslow_exp = 2.55 (ms) <1e-9,1e9>    : slow decay
    afast = 0.75 <0,1>
	  e=0	(mV)
    fracca= 0.002        : fraction of current that is ca ions
    z = 2
    celsius = 22	(degC)
    T_exp = 22    (degC)
    q10 = 3
}

ASSIGNED {
    v       (mV)
    i       (nA)
    ica	    (nA) 	
    g       (uS)
    aslow 
    total   (uS)
    cai     (mM)
    cao     (mM)
    taurise (ms)
    taufast (ms)
    tauslow (ms)
    normfac 
}

BREAKPOINT {
	  SOLVE state METHOD cnexp
    g = (B + C - A) 
    i =   g * (1-fracca) * (v - e)
    ica = g * fracca     * ghkg(v,cai,cao,z)
}

INCLUDE "triexpsyn.inc"

INCLUDE "ghk.inc"



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