CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy PLoS Comput Biol 8(6):e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
/
bpap
CA1_multi
lib
basic_graphics.hoc *
basic-graphics.hoc *
choose-secs.hoc *
current-balance.hoc *
cut-sections.hoc *
deduce-ratio.hoc *
find-gmax.hoc *
GABA_shiftsyn.hoc *
GABA_shiftsyn_bg.hoc *
ken.h *
map-segments-to-3d.hoc *
maxmin.hoc *
newshiftsyn.exe *
num-rec.h *
salloc.hoc *
shiftsyn-init_bg.hoc *
shiftsyn-initA.hoc *
spikecount.hoc *
tune-epsps.hoc *
vector-distance.hoc *
verbose-system.hoc *
                            
// This function is used to balance the membrane potential to v_init (= -70 mV)
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

proc current_balance() {

 // print "Note: This does not account for non-specific ion currents.\n"

  finitialize($1)
  fcurrent()

  printf("Balancing each compartment to %d mV\n", $1)

  forall {
      for (x) {
        if (ismembrane("na_ion") && ismembrane("ca_ion") && ismembrane("Ca_ion") && (ismembrane("k_ion"))) {
            e_pas(x)=(ina(x)+ik(x)+ica(x)+iCa(x)+g_pas(x)*v(x))/g_pas(x) 
        } else if (ismembrane("na_ion") && ismembrane("ca_ion") && (ismembrane("k_ion"))){
            e_pas(x)=(ina(x)+ik(x)+ica(x)+g_pas(x)*v(x))/g_pas(x) 
        } else if (ismembrane("na_ion") && (ismembrane("k_ion"))) {
            e_pas(x)=(ina(x)+ik(x)+g_pas(x)*v(x))/g_pas(x)
          //printf("Section %s ina: %g ik: %g\n", secname(), ina(x), ik(x))
          //psection()
        } else {
          print "simply assigning v(x)"
          e_pas(x)=v(x)
        }
      fcurrent()
    }
  }
}

Loading data, please wait...