CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy PLoS Comput Biol 8(6):e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
basic_graphics.hoc *
basic-graphics.hoc *
choose-secs.hoc *
current-balance.hoc *
cut-sections.hoc *
deduce-ratio.hoc *
find-gmax.hoc *
GABA_shiftsyn.hoc *
GABA_shiftsyn_bg.hoc *
ken.h *
map-segments-to-3d.hoc *
maxmin.hoc *
newshiftsyn.exe *
num-rec.h *
salloc.hoc *
shiftsyn-init_bg.hoc *
shiftsyn-initA.hoc *
spikecount.hoc *
tune-epsps.hoc *
vector-distance.hoc *
verbose-system.hoc *
// For each section location, define x,y,z coordinates so it can be
// displayed in 3-D

proc endpt() {


proc fracpt() { local posn, A
  x_d3(posn)=x3d(i-1) + (x3d(i) - x3d(i-1))*A
  y_d3(posn)=y3d(i-1) + (y3d(i) - y3d(i-1))*A
  z_d3(posn)=z3d(i-1) + (z3d(i) - z3d(i-1))*A

proc map_segments_to_3d() {

    forall {
    insert d3

    for (x) if (x > 0 && x < 1) {

      while (arc3d(i)/L < x) {
        i += 1
      D=arc3d(i) - arc3d(i-1)
      if (D <= 0) {
      printf("\t\t * %s had a D < 0\n", secname())
      alpha = (x*L - arc3d(i-1))/D



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