CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy PLoS Comput Biol 8(6):e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
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bpap
CA1_multi
mechanism
cad.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
h.mod *
hha_old.mod *
hha2.mod *
kadist.mod *
kaprox.mod *
kca.mod *
km.mod *
nap.mod *
nmda.mod *
somacar.mod *
mosinit.hoc.old *
mosinit.poirazi.hoc *
                            
// mosinit.hoc for mswin and unix version of Poirazi et al model. 6/22/04 TMM

objref box

// debug statements below remind me that new auto-launch starts up with
// current directory (working directory) set to wherever mosinit.hoc is.
// system("pwd")
// print "press return"
// system("read a")

if (unix_mac_pc() ==1 ) { // note if your sys has stdlib.h and string.h this will work however
			  // NEURON's mswin shell comes without these.  If cygwin is added to
			  // your mswin system though you will receive these extra items.
	system("cd ../lib; gcc -o newshiftsyn newshiftsyn.c -Ilib -lm")
}

if (unix_mac_pc() ==1 || unix_mac_pc() ==3 ) {
	// system("cd lib; gcc -o newshiftsyn newshiftsyn.c -Ilib -lm")
	load_file("nrngui.hoc")
	objref box
	box=new VBox()
	box.intercept(1)
		xpanel("")
		xlabel("Sample Runs")
		xbutton("hyperpolarization-current", "unix_hyper_cur()")
		xlabel("Spike-Train-Attenutation")
		xbutton("Hofman traces", "unix_spike_atten_hof()")
		xbutton("Back Propagating APs", "unix_spike_atten_bpap()")
		xpanel()
	box.intercept(0)
	box.map("Numerical Experiments")
} else  {
	print "not configured for mac yet"
	print "press return"
	read(a)
	quit()
}

proc unix_hyper_cur() {
	chdir("../experiment/hyperpolarization-current")
	load_file("H_current.hoc")
	chdir("..")	// back to one directory below root for other buttons to work
}

proc unix_spike_atten_hof() {
	chdir("../experiment/spike-train-attenuation")
	load_file("Hofman_traces.hoc")
	chdir("..")	// back to one directory below root for other buttons to work
}

proc unix_spike_atten_bpap() {
	chdir("../experiment/spike-train-attenuation")
	load_file("bpap.hoc")
	chdir("..")	// back to one directory below root for other buttons to work
}

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