CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS Comput Biol 8:e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
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bpap
CA1_multi
mechanism
cad.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
h.mod *
hha_old.mod *
hha2.mod *
kadist.mod *
kaprox.mod *
kca.mod *
km.mod *
nap.mod *
nmda.mod *
somacar.mod *
mosinit.hoc.old *
mosinit.poirazi.hoc *
                            
TITLE  Na persistent channel
: used in distal oblique dendrites to assist Ca spike initiation  
: a typo in the exponential function was pointed out by Michele Migliore and
: corrected by Yiota Poirazi on December 4th, 2003
NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
        RANGE  gnabar,vhalf, K

}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

PARAMETER {                         : parameters that can be entered when function is called in cell-setup 
        dt (ms) 
	v (mV)
        ena = 50           (mV)     : Na reversal potential  (reset in cell-setup.hoc)
	K = 4.5            (1)      : slope of steady state variable
:	gnabar = 0.001e-2 (mho/cm2) : suggested conductance, 1 percent of the transient Na current
	gnabar = 0                  : initialized conductance
	vhalf  = -50.4    (mV)      : half potential
}	

STATE { n }

ASSIGNED {
	ina (mA/cm2)
}

INITIAL {
:	SOLVE states
}

BREAKPOINT {
	SOLVE states
	ina = gnabar*n*n*n*(v-ena)
}

PROCEDURE states() {     : exact when v held constant; integrates over dt step

:        n = 1 / (1 + (exp(vhalf - v))/K) : steady state value !!!typo in the exponential function!!!

        n = 1 / (1 + (exp(vhalf - v)/K)) : steady state value
        VERBATIM
        return 0;
        ENDVERBATIM
}
















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