State and location dependence of action potential metabolic cost (Hallermann et al., 2012)

 Download zip file   Auto-launch 
Help downloading and running models
With this model of a layer 5 pyramidal neuron the state and location dependence of the ATP usage and the metabolic efficiency of action potentials can be analyzed. Model parameters were constrained by direct subcellular recordings at dendritic, somatic and axonal compartments.
1 . Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012) State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci 15:1007-14 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Action Potentials;
Implementer(s): Hallermann, Stefan [hallermann at]; Kole, Maarten [m.kole at];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; I Na,t; I K;
readme.txt *
Cad.mod *
CaH.mod *
CaT.mod *
charge.mod *
h.mod *
Kca.mod *
Kv.mod *
Kv1_axonal.mod *
Kv7.mod *
28_04_10_num19.hoc * *
Cell parameters.hoc
charge.hoc *
mosinit.hoc *
File not selected

<- Select file from this column.
Loading data, please wait...