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Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
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These models predict the differential effects of varying pathways of inactivation (closed state inactivation, CSI, or open state inactivation, OSI). Specifically, Markov models of Kv4 potassium channels with CSI or CSI+OSI were inserted into the CA1 pyramidal neuron model from Migliore et al (1999; ModelDB accession #2796) to determine the neurophysiological impact of inactivation pathways. Furthermore, Markov models of Kv4.2 and Kv3.4 channels are used to illustrate a method by which to test what pathway of inactivation a channel uses.
Fineberg JD, Ritter DM, Covarrubias M (2012) Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels.
J Gen Physiol
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
Ion Channel Kinetics;
Ritter, David [david.ritter at jefferson.edu];
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Hippocampus CA1 pyramidal GLU cell
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