Oversampling method to extract excitatory and inhibitory conductances (Bedard et al. 2012)

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Accession:145803
" ... We present here a new method that allows extracting estimates of the full time course of excitatory and inhibitory conductances from single-trial Vm recordings. This method is based on oversampling of the Vm . We test the method numerically using models of increasing complexity. Finally, the method is evaluated using controlled conductance injection in cortical neurons in vitro using the dynamic-clamp technique. ..."
Reference:
1 . Bédard C, Béhuret S, Deleuze C, Bal T, Destexhe A (2012) Oversampling method to extract excitatory and inhibitory conductances from single-trial membrane potential recordings. J Neurosci Methods 210:3-14 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
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Simulation Environment: MATLAB;
Model Concept(s): Parameter Fitting; Methods;
Implementer(s): Bedard, Claude [bedard at unic.cnrs-gif.fr];
function  [tt1 vv1 ] = eqdifferentielleR(tt,aa,bb,condinitiale)

                      % method for exact solution
                                 vv(1) = condinitiale;
                           for n=2 :length(tt)
                               dtt = tt(n)-tt(n-1);
                                y = bb(n)/aa(n);
                                x = exp(aa(n)*dtt);
                                
                                vv(n) = vv(n-1)*x -y*(1-x);
                                
                           end
                           
                           
                           tt1=tt; vv1=vv;

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