Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)

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Accession:146376
"... Here we introduce a new, automatic and fast method to map realistic neurons into equivalent reduced models running up to >40 times faster while maintaining a very high accuracy of the membrane potential dynamics during synaptic inputs, and a direct link with experimental observables. The mapping of arbitrary sets of synaptic inputs, without additional fine tuning, would also allow the convenient and efficient implementation of a new generation of large-scale simulations of brain regions reproducing the biological variability observed in real neurons, with unprecedented advances to understand higher brain functions."
Reference:
1 . Marasco A, Limongiello A, Migliore M (2012) Fast and accurate low-dimensional reduction of biophysically detailed neuron models Scientific Reports 2:928:1-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Detailed Neuronal Models;
Implementer(s): Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; I Na,t; I A; I K; I h;
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SoftReduction1.0.doc
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Marasco A, Limongiello A, Migliore M (2012) Fast and accurate low-dimensional reduction of biophysically detailed neuron models Scientific Reports 2:928:1-7[PubMed]

References and models cited by this paper

References and models that cite this paper

Bhalla US, Bower JM (1993) Exploring parameter space in detailed single neuron models: simulations of the mitral and granule cells of the olfactory bulb. J Neurophysiol 69:1948-65 [Journal] [PubMed]

   Granule Cells of the Olfactory Bulb (Simoes_De_Souza et al. 2014) [Model]
   Olfactory Mitral Cell (Bhalla, Bower 1993) [Model]

Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons J Comput. Neurosci. 33:207-25 [Journal] [PubMed]

   CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012) [Model]

Brown SA, Moraru II, Schaff JC, Loew LM (2011) Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling. J Comput Neurosci 31(2):385-400 [Journal] [PubMed]

   A simplified cerebellar Purkinje neuron (the PPR model) (Brown et al. 2011) [Model]

Bush PC, Sejnowski TJ (1993) Reduced compartmental models of neocortical pyramidal cells. J Neurosci Methods 46:159-66 [PubMed]

Colgin LL, Moser EI (2010) Gamma oscillations in the hippocampus. Physiology (Bethesda) 25:319-29 [PubMed]

Destexhe A (2001) Simplified models of neocortical pyramidal cells preserving somatodendritic voltage attenuation Neurocomputing 38-40:167-173

Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 18:3574-88 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]
   Low Threshold Calcium Currents in TC cells (Destexhe et al 1998) [Model]

Druckmann S, Berger TK, Schürmann F, Hill S, Markram H, Segev I (2011) Effective stimuli for constructing reliable neuron models. PLoS Comput Biol 7:e1002133 [Journal] [PubMed]

Gasparini S, Migliore M, Magee JC (2004) On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. J Neurosci 24:11046-11056 [Journal] [PubMed]

   CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004) [Model]

Gugercin S, Antoulas A, Beattie C (2008) H2 model reduction for large-scale linear dynamical systems Siam J Matrix An Appl 30:609-638

Hendrickson EB, Edgerton JR, Jaeger D (2011) The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. J. Comp. Neurosci. 30(2):301-321 [Journal] [PubMed]

   Comparison of full and reduced globus pallidus models (Hendrickson 2010) [Model]

Herz AV, Gollisch T, Machens CK, Jaeger D (2006) Modeling single-neuron dynamics and computations: a balance of detail and abstraction. Science 314:80-5 [PubMed]

Hill SL, Wang Y, Riachi I, Schurmann F, Markram H (2012) Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits. Proc Natl Acad Sci U S A 109:E2885-94 [PubMed]

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hines ML, Carnevale NT (2001) NEURON: a tool for neuroscientists. Neuroscientist 7:123-35 [Journal] [PubMed]

   Spatial gridding and temporal accuracy in NEURON (Hines and Carnevale 2001) [Model]

Kellems AR, Chaturantabut S, Sorensen DC, Cox SJ (2010) Morphologically accurate reduced order modeling of spiking neurons. J Comput Neurosci 28:477-94 [PubMed]

Kellems AR, Roos D, Xiao N, Cox SJ (2009) Low-dimensional, morphologically accurate models of subthreshold membrane potential. J Comput Neurosci 27:161-76 [PubMed]

Markram H (2006) The blue brain project. Nat Rev Neurosci 7:153-60 [Journal] [PubMed]

   [241 reconstructed morphologies on NeuroMorpho.Org]

Migliore M (2003) On the Integration of Subthreshold Inputs from Perforant Path and Schaffer Collaterals in Hippocampal CA1 Pyramidal Neurons. J Comput Neurosci 14:185-192 [Journal] [PubMed]

   CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003) [Model]

Migliore M, Ferrante M, Ascoli GA (2005) Signal propagation in oblique dendrites of CA1 pyramidal cells. J Neurophysiol 94:4145-4155 [Journal] [PubMed]

   CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005) [Model]

Migliore M, Shepherd GM (2005) Opinion: an integrated approach to classifying neuronal phenotypes. Nat Rev Neurosci 6:810-8 [Journal] [PubMed]

Miles R, Traub RD (1991) Neuronal Networks of the Hippocampus

Morgan RJ, Soltesz I (2008) Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proc Natl Acad Sci U S A 105:6179-84 [Journal] [PubMed]

   Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007) [Model]

Narayanan R, Johnston D (2008) The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons. J Neurosci 28:5846-60 [Journal] [PubMed]

   Resonance properties through Chirp stimulus responses (Narayanan Johnston 2007, 2008) [Model]

Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60 [Journal] [PubMed]

   CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994) [Model]

Postlethwaite M, Hennig MH, Steinert JR, Graham BP, Forsythe ID (2007) Acceleration of AMPA receptor kinetics underlies temperature-dependent changes in synaptic strength at the rat calyx of Held. J Physiol 579:69-84 [Journal] [PubMed]

   Modeling temperature changes in AMPAR kinetics (Postlethwaite et al 2007) [Model]

RALL W (1959) Branching dendritic trees and motoneuron membrane resistivity. Exp Neurol 1:491-527 [PubMed]

Rall W (1995) The Theoretical Foundation Of Dendritic Function, Segev I:Rinzel J:Shepherd GM, ed.

Santhakumar V, Aradi I, Soltesz I (2005) Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol 93:437-53 [Journal] [PubMed]

   Dentate gyrus network model (Santhakumar et al 2005) [Model]
   Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007) [Model]

Sejnowski T (2010) When Will We Be Able to Build Brains Like Ours? Scientific American

Stratford KJ, Mason AJR, Larkman AU, Major G, Jack JJB (1989) The modelling of pyramidal neurones in the visual cortex The Computing Neuron, Durbin R:Miall C:Mitchison G, ed. pp.296

Tobin AE, Van Hooser SD, Calabrese RL (2006) Creation and reduction of a morphologically detailed model of a leech heart interneuron. J Neurophysiol 96:2107-20 [Journal] [PubMed]

Whittington MA, Cunningham MO, LeBeau FE, Racca C, Traub RD (2011) Multiple origins of the cortical gamma rhythm. Dev Neurobiol 71(1):92-106 [Journal] [PubMed]

Marasco A, Limongiello A, Migliore M (2013) Using Strahler`s analysis to reduce up to 200-fold the run time of realistic neuron model Sci. Rep. 3:2934 [Journal] [PubMed]

   Using Strahler`s analysis to reduce realistic models (Marasco et al, 2013) [Model]

(34 refs)