Paradoxical GABA-mediated excitation (Lewin et al. 2012)

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Accession:146504
"GABA is the key inhibitory neurotransmitter in the adult central nervous system, but in some circumstances can lead to a paradoxical excitation that has been causally implicated in diverse pathologies from endocrine stress responses to diseases of excitability including neuropathic pain and temporal lobe epilepsy. We undertook a computational modeling approach to determine plausible ionic mechanisms of GABAA-dependent excitation in isolated post-synaptic CA1 hippocampal neurons because it may constitute a trigger for pathological synchronous epileptiform discharge. In particular, the interplay intracellular chloride accumulation via the GABAA receptor and extracellular potassium accumulation via the K/Cl co-transporter KCC2 in promoting GABAA-mediated excitation is complex. ..."
Reference:
1 . Lewin N, Aksay E, Clancy CE (2012) Computational Modeling Reveals Dendritic Origins of GABA(A)-Mediated Excitation in CA1 Pyramidal Neurons. PLoS One 7:e47250 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; Na/Ca exchanger; Na/K pump; KCC2; NKCC1; Ca pump;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Bursting; Detailed Neuronal Models; Epilepsy; Calcium dynamics; Markov-type model;
Implementer(s): Clancy, Colleen E [ceclancy at ucdavis.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; Na/Ca exchanger; Na/K pump; KCC2; NKCC1; Ca pump;
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Naomi_CA1_code
results
readme.html
dist_list
get_morphology.cpp
get_morphology.h
interneuron_update.cpp
interneuron_update.h
ion_transport.cpp
ion_transport.h
main.cpp
Makefile
mySim
n123 copy.txt *
n123.rtf
n123.txt *
n123_neighborslist copy.txt *
n123_neighborslist.csv
n123_neighborslist.txt *
n123_trim copy.txt *
n123_trim.txt *
neuron_structures.h
nr.cpp
nr.h
nrtypes.h *
nrtypes_nr.h *
nrutil.h *
nrutil_nr.h *
read_morphology.cpp
sodium.h
steady_state.h
stimulations.h
synaptic_channels.cpp
synaptic_channels.h
update.cpp
update.h
vgated_channels.cpp
vgated_channels.h
vgated_kcurrents.h
                            
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