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Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
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"... We developed a computational model based primarily on a unified set of brain activity mapping studies of mouse M1. The simulation consisted of 775 spiking neurons of 10 cell types with detailed population-to-population connectivity. Static analysis of connectivity with graph-theoretic tools revealed that the corticostriatal population showed strong centrality, suggesting that would provide a network hub. ... By demonstrating the effectiveness of combined static and dynamic analysis, our results show how static brain maps can be related to the results of brain activity mapping."
Chadderdon GL, Mohan A, Suter BA, Neymotin SA, Kerr CC, Francis JT, Shepherd GM, Lytton WW (2014) Motor cortex microcircuit simulation based on brain activity mapping.
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Neocortex V1 L6 pyramidal corticothalamic cell;
Neocortex M1 L2/6 pyramidal intratelencephalic cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Lytton, William [bill.lytton at downstate.edu];
Neymotin, Sam [samn at neurosim.downstate.edu];
Shepherd, Gordon MG [g-shepherd at northwestern.edu];
Chadderdon, George [gchadder3 at gmail.com];
Kerr, Cliff [cliffk at neurosim.downstate.edu];
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Neocortex V1 L6 pyramidal corticothalamic cell
Neocortex M1 L2/6 pyramidal intratelencephalic cell
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