Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)

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Accession:147141
Learning in the brain requires complementary mechanisms: potentiation and activity-dependent homeostatic scaling. We introduce synaptic scaling to a biologically-realistic spiking model of neocortex which can learn changes in oscillatory rhythms using STDP, and show that scaling is necessary to balance both positive and negative changes in input from potentiation and atrophy. We discuss some of the issues that arise when considering synaptic scaling in such a model, and show that scaling regulates activity whilst allowing learning to remain unaltered.
Reference:
1 . Rowan MS, Neymotin SA (2013) Synaptic Scaling Balances Learning in a Spiking Model of Neocortex Adaptive and Natural Computing Algorithms, Tomassini M, Antonioni A, Daolio F, Buesser P, ed. pp.20
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Abstract integrate-and-fire adaptive exponential (AdEx) neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Learning; STDP; Homeostasis;
Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]; Rowan, Mark [m.s.rowan at cs.bham.ac.uk];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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stdpscalingpaper
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// $Id: default.hoc,v 1.5 2003/07/08 16:16:52 billl Exp $
/* This file contains various global defaults for hoc

** Users should not edit nrnoc.hoc or default.hoc.  Any local 
changes to these files should be made in local.hoc.
----------------------------------------------------------------*/

/*------------------------------------------------------------
Object defaults
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/*** Define a "nil" object ***/
objectvar nil

/*------------------------------------------------------------
String defaults
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/*** "Section" is used if errors are found in the initializiations ***/
strdef section

/*** Misc defines used by graphic routines ***/
temp_string_ = "t"
tempvar = 0

/*------------------------------------------------------------
Simulation defaults
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                        /* To be consistent w/the nmodl values */
FARADAY = 96520.        /* Hoc default = 96484.56 */
PI      = 3.14159       /* Hoc default = 3.1415927 */

                        /* 0=off, 1=on */
print_flag  = 0         /* Write to output file */
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iv_flag     = 1         /* Using Interviews plotting */
batch_flag  = 0         /* Using batch_run() */
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stoprun     = 0         /* 0=running, 1=stopped */
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run_seed    = 680612

t           = 0         /* msec */
dt          = .01       /* msec */
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printStep   = 0.1       /* msec */
plotStep    = 0.1       /* msec */
flushStep   = 0.1       /* msec */
eventStep   = 50        /* Number of nstep's before a doEvent */

secondorder = 0

celsius     = 6.3       /* degC */

v_init      = -70       /* (mV) */
global_ra   = 200       /* (ohm-cm) specific axial resisitivity */

/*** Ion parameters ***/
ca_init     = 50e-6     /* mM */
na_init     = 10        /* mM */
k_init      = 54.4      /* mM */


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