Region-specific atrophy in dendrites (Narayanan, Narayan, Chattarji, 2005)

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Accession:147756
...in this study, we develop an algorithm that uses statistics from precise morphometric analyses to systematically remodel neuronal reconstructions. We use the distribution function of the ratio of two normal distributed random variables to specify the probabilities of remodeling along various regions of the dendritic arborization. We then use these probabilities to drive an iterative algorithm for manipulating the dendritic tree in a region-specific manner. As a test, we apply this framework to a well characterized example of dendritic remodeling: stress-induced dendritic atrophy in hippocampal CA3 pyramidal cells. We show that our pruning algorithm is capable of eliciting atrophy that matches biological data from rodent models of chronic stress. <br>
Reference:
1 . Narayanan R, Narayan A, Chattarji S (2005) A probabilistic framework for region-specific remodeling of dendrites in three-dimensional neuronal reconstructions. Neural Comput 17:75-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Influence of Dendritic Geometry;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell;
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1300 3 116.96 -203.264 -25.75 0.4 1299
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1302 3 123.73 -206.522 -25.5 0.4 1301
1303 3 127.358 -209.962 -25.5 0.4 1302
1304 3 24.007 -51.631 -9.5 0.72 1240
1305 3 25.908 -53.812 -8 0.56 1304
1306 3 25.696 -53.812 -8 0.56 1305
1307 3 28.449 -53.147 -8 0.56 1306
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1309 3 28.662 -60.116 -8 0.56 1308
1310 3 27.81 -64.252 -3.25 0.56 1309
1311 3 27.81 -64.026 -3.25 0.56 1310
1312 3 28.236 -70.118 -4.5 0.56 1311
1313 3 28.874 -75.996 -6 0.56 1312
1314 3 29.712 -76.435 -6 0.56 1313
1315 3 29.712 -76.435 -5.975 0.4 1314
1316 3 35.006 -79.481 -9.5 0.4 1315
1317 3 36.07 -82.088 -9.25 0.4 1316
1318 3 39.887 -84.921 -9.25 0.4 1317
1319 3 43.691 -91.664 -9.25 0.4 1318
1320 3 47.508 -97.316 -2 0.24 1319
1321 3 49.835 -103.62 -2 0.24 1320
1322 3 49.835 -103.408 -2 0.24 1321
1323 3 53.227 -111.241 -1 0.24 1322
1324 3 54.916 -119.075 -8.5 0.24 1323
1325 3 55.98 -124.076 -6.25 0.24 1324
1326 3 56.605 -127.56 -7.5 0.24 1325
1327 3 61.898 -136.91 -0.75 0.24 1326
1328 3 64.864 -141.911 -8.5 0.24 1327
1329 3 68.256 -151.7 -2.5 0.24 1328
1330 3 70.796 -156.927 -2.25 0.24 1329
1331 3 70.583 -156.927 -2.25 0.24 1330
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1333 3 69.945 -159.746 7.5 0.24 1332
1334 3 73.336 -162.792 -5 0.24 1333
1335 3 74.5175 -165.539 -4.7573 0.24 1334
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1339 3 32.053 -82.088 -3.5 0.4 1338
1340 3 32.053 -81.875 -3.5 0.4 1339
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1344 3 31.415 -91.438 -4.5 0.4 1343
1345 3 29.3 -93.406 5 0.4 1344
1346 3 28.874 -99.71 1.75 0.4 1345
1347 3 26.746 -102.317 1.75 0.4 1346
1348 3 26.746 -102.104 1.75 0.4 1347
1349 3 27.385 -108.634 1.5 0.4 1348
1350 3 27.81 -113.196 1.5 0.4 1349
1351 3 29.3 -116.029 1.25 0.4 1350
1352 3 28.662 -125.818 0.5 0.4 1351
1353 3 27.385 -128.638 0.5 0.4 1352
1354 3 28.449 -131.909 0.5 0.4 1353
1355 3 25.696 -135.82 0.5 0.4 1354
1356 3 25.057 -139.091 1 0.4 1355
1357 3 26.334 -143.002 1.25 0.4 1356
1358 3 26.334 -143.214 1.25 0.4 1357
1359 3 24.632 -146.699 1.5 0.4 1358
1360 3 24.007 -154.094 1.25 0.4 1359
1361 3 24.007 -162.792 1.5 0.4 1360
1362 3 24.419 -172.155 11.75 0.4 1361
1363 3 25.6307 -176.987 11.3229 0.4 1362
1364 3 17.862 -39.009 -13.475 0.56 1236
1365 3 22.517 -43.145 -10.25 0.56 1364
1366 3 27.81 -44.675 -10.25 0.56 1365
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1370 3 37.546 -50.766 -27.5 0.4 1369
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1373 3 55.129 -58.813 -29 0.4 1372
1374 3 54.916 -58.813 -28.75 0.4 1373
1375 3 57.789 -61.526 -25 0.56 1374
1376 3 62.71 -62.204 -4.5 0.56 1375
1377 3 65.436 -61.818 -26.75 0.56 1376
1378 3 65.489 -62.031 -19.5 0.56 1377
1379 3 69.399 -67.843 -30.5 0.56 1378
1380 3 78.098 -69.918 -30 0.56 1379
1381 3 78.35 -70.078 -29.25 0.56 1380
1382 3 78.35 -70.078 -29.225 0.4 1381
1383 3 80.146 -75.065 -19.75 0.4 1382
1384 3 86.277 -77.26 -19.75 0.4 1383
1385 3 86.237 -77.047 -19.75 0.4 1384
1386 3 89.31 -80.146 -43.5 0.4 1385
1387 3 94.39 -83.471 -47.25 0.4 1386
1388 3 94.35 -83.258 -47.25 0.4 1387
1389 3 101.213 -87.74 -26.5 0.4 1388
1390 3 101 -87.793 -26.5 0.4 1389
1391 3 106.546 -91.238 -59.25 0.4 1390
1392 3 117.399 -97.05 -44.25 0.4 1391
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1402 3 169.642 -133.745 -77.75 0.4 1401
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1404 3 187.051 -143.68 -89.25 0.4 1403
1405 3 188.002 -143.801 -91.0054 0.4 1404
1406 3 78.151 -70.131 -29.25 0.56 1381
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1409 3 85.253 -80.571 -41 0.4 1408
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1411 3 86.157 -84.601 -41 0.4 1410
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1414 3 95.627 -87.168 -44.5 0.4 1413
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1416 3 98.753 -87.581 -58.75 0.4 1415
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1422 3 119.926 -94.896 -76.25 0.4 1421
1423 3 130.167 -99.963 -78.25 0.24 1422
1424 3 139.012 -105.562 -79.25 0.24 1423
1425 3 147.218 -109.299 -94.25 0.24 1424
1426 3 154.28 -111.733 -97 0.24 1425
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1429 3 161.249 -115.75 -105 0.24 1428
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1431 3 166.995 -122.041 -104 0.24 1430
1432 3 166.955 -121.828 -104 0.24 1431
1433 3 169.256 -125.326 -103.5 0.24 1432
1434 3 65.489 -62.031 -19.475 0.4 1378
1435 3 68.3725 -62.6243 -18.8977 0.4 1434
1436 1 -1.476 -10.002 1 5.01 1226
1437 1 -1.689 -11.744 1 4.69 1436
1438 1 -1.064 -13.712 1 3.58 1437
1439 1 -1.064 -14.79 1 2.63 1438
1440 1 -0.638 -15.88 1 1.83 1439
1441 1 -0.638 -16.532 1 1.83 1440

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