Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)

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Accession:147757
The role of amyloid beta (Aß) in brain function and in the pathogenesis of Alzheimer’s disease remains elusive. Recent publications reported that an increase in Aß concentration perturbs presynaptic release in hippocampal neurons, in particular by increasing release probability of CA3-CA1 synapses. The model predics how this alteration can affect synaptic plasticity and signal integration. The results suggest that the perturbation of release probability induced by increased Aß can significantly alter the spike probability of CA1 pyramidal neurons and thus contribute to abnormal hippocampal function during Alzheimer’s disease.
Reference:
1 . Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H (2013) Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Front Comput Neurosci 7:1 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Synaptic Integration; Aging/Alzheimer`s;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Romani, Armando [romani.armando -at- gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I M; I h; I Calcium; I_AHP; Glutamate;
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RomaniEtAl2013
experiment
cad.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
d3.mod *
h.mod *
kadist.mod *
kaprox.mod *
kca.mod *
kdr.mod *
km.mod *
na3.mod *
na3dend.mod *
na3notrunk.mod *
nap.mod *
nax.mod *
netstimmm.mod *
somacar.mod *
tmgsyn.mod
vecevent.mod
cell-setup.hoc
createNewSyn4.hoc
loadBasicModel.hoc
mosinit.hoc
session.ses
simulation.hoc
                            
BACK_GROUND = 0 		// set to 1 when using background synapses
synch = 0  			// synapses are stimulated randomly (NOT synchronously), set to 1 for synchronous stimulation

load_file("nrngui.hoc")
load_file("./../template/ExperimentControl.hoc")       // load needed templates
load_file("./../template/RangeRef.hoc")
load_file("./../template/ObliquePath.hoc")
load_file("./../template/BasalPath.hoc")

cvode_active(0)						//activate Cvode

objref econ                              		// initialize template parameters
show_errs=1
debug_lev=1
econ=new ExperimentControl(show_errs,debug_lev)
econ.self_define(econ)
econ.morphology_dir="./../morphology/n123"              // set location for morphology files
econ.add_lib_dir("Terrence","./../lib")                 // set location for library files
econ.generic_dir="./../experiment/"                     // set 
strdef tips_dir

system(econ.syscmd)

actual_resolution=75                               // maximum nseg number, lib/chooses-secs.hoc 
desired_resolution=1

xopen("./../morphology/n123/cell.hoc")			// load raw cell morphology     
xopen("./../morphology/n123/cell-analysis.hoc")	// load user-defined semantics on morphology                                  	
cell_analysis(econ)
 
printf("Opening cell setup\n")                                   
                                              
xopen("./cell-setup.hoc")				// load cell-setup
printf("Opened. Setting up cell\n")                     // specify all mechanisms,
maximum_segment_length=actual_resolution                // membrane properties etc	 
cell_setup(econ)


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