Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)

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Accession:147757
The role of amyloid beta (Aß) in brain function and in the pathogenesis of Alzheimer’s disease remains elusive. Recent publications reported that an increase in Aß concentration perturbs presynaptic release in hippocampal neurons, in particular by increasing release probability of CA3-CA1 synapses. The model predics how this alteration can affect synaptic plasticity and signal integration. The results suggest that the perturbation of release probability induced by increased Aß can significantly alter the spike probability of CA1 pyramidal neurons and thus contribute to abnormal hippocampal function during Alzheimer’s disease.
Reference:
1 . Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H (2013) Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Front Comput Neurosci 7:1 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Synaptic Integration; Aging/Alzheimer`s;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Romani, Armando [romani.armando -at- gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I M; I h; I Calcium; I_AHP; Glutamate;
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RomaniEtAl2013
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
n123.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function makes a list with primary oblique dendrites
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_tip_list
apical_tip_list=new SectionList()

// List of obliques located at distances approximatelly less than 300 microns from the soma

proc proximals() {

  apical_dendrite[3]    apical_tip_list.append()   // 1 degree                 74.4  microns from soma
  apical_dendrite[5]    apical_tip_list.append()   // 0 degree                 57.46 (vertical distance)
  apical_dendrite[24]   apical_tip_list.append()   // 0 degree                 92.05
  apical_dendrite[30]   apical_tip_list.append()   // 0 degree  (essentially) 153.44
  apical_dendrite[34]   apical_tip_list.append()   // 2 degrees (ignore 3rd)  215.06
  apical_dendrite[45]   apical_tip_list.append()   // 0 degree. (essentially) 170.32
  apical_dendrite[51]   apical_tip_list.append()   // 2 degrees               210.93
  apical_dendrite[59]   apical_tip_list.append()   //                         189.34
  apical_dendrite[61]   apical_tip_list.append()   //                         221.55
  apical_dendrite[63]   apical_tip_list.append()   //                         231.58
  apical_dendrite[68]   apical_tip_list.append()   // 2 degrees               277.48
  apical_dendrite[70]   apical_tip_list.append()   // 0 degree                300.94
  apical_dendrite[106]  apical_tip_list.append()   // 0 degree                258.05
  apical_dendrite[107]  apical_tip_list.append()   // 0 degree                159.55      
  apical_dendrite[111]  apical_tip_list.append()   // 1 degree                106.30
  apical_dendrite[112]  apical_tip_list.append()   // 0 degree                 88.52
  apical_dendrite[115]  apical_tip_list.append()   // 1 degree                117.79
  apical_dendrite[118]  apical_tip_list.append()   // 0 degree                 81.66
}

// List of obliques located beyond 300 microns from the soma

proc distals() {    
  apical_dendrite[73]   apical_tip_list.append()   // 0 degree                334.84 
  apical_dendrite[82]   apical_tip_list.append()   // 0 degree                360.28
  apical_dendrite[86]   apical_tip_list.append()   // 0 degree                419.68
  apical_dendrite[93]   apical_tip_list.append()   // 0 degree                468.60
  apical_dendrite[97]   apical_tip_list.append()   // 0 degree                445.90
  apical_dendrite[105]  apical_tip_list.append()   // 0 degree                425.58
}

proximals()
distals()

/* Make a shape graph with apical oblique dendrites
objref apical_tip_list_shape
color_index = 2
apical_tip_list_shape=new Shape()
apical_tip_list_shape.color_list(apical_tip_list,color_index)
apical_tip_list_shape.action("secname()")
apical_tip_list_shape.printfile("apical-tip-list.eps")
*/

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