Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)

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Accession:147757
The role of amyloid beta (Aß) in brain function and in the pathogenesis of Alzheimer’s disease remains elusive. Recent publications reported that an increase in Aß concentration perturbs presynaptic release in hippocampal neurons, in particular by increasing release probability of CA3-CA1 synapses. The model predics how this alteration can affect synaptic plasticity and signal integration. The results suggest that the perturbation of release probability induced by increased Aß can significantly alter the spike probability of CA1 pyramidal neurons and thus contribute to abnormal hippocampal function during Alzheimer’s disease.
Reference:
1 . Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H (2013) Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Front Comput Neurosci 7:1 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Synaptic Integration; Aging/Alzheimer`s;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Romani, Armando [romani.armando -at- gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I M; I h; I Calcium; I_AHP; Glutamate;
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RomaniEtAl2013
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
n123.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function loads all morphology-related files and templates that will 
// most probably be needed in the experiments to follow.
// written by Terrence Brannon, modified Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref vRP, vAPEX

proc cell_analysis() {

  load_template("ObliquePath")
  load_template("BasalPath")

  forall insert d3   // mod file to enable 3-D mapping of each point along the cell

  $o1.defvar("Distance Calculation", "adjustment", "41.1", "This adjustment factor is supplied to the vector distance function so that distance calculations are measured at the cell body.")

  $o1.xopen_library("Terrence","vector-distance")

  vRP=new Vector()
  access  apical_dendrite[4]   // set point of reference (if adjustment=0). With adjustment factor = 41.1
  vcreate(vRP)                 // the point of reference is the soma

  vAPEX=new Vector()
  access apical_dendrite[92]  // set the apex point
  vcreate2(vAPEX,0.5)

  $o1.xopen_geometry_dependent("soma-list")
  $o1.xopen_geometry_dependent("axon-sec-list")
  $o1.xopen_geometry_dependent("basal-tree-list")
  $o1.xopen_geometry_dependent("apical-tip-list")
  $o1.xopen_geometry_dependent("apical-tip-list-addendum")
  $o1.xopen_geometry_dependent("apical-trunk-list")
  $o1.xopen_geometry_dependent("peri-trunk-list")
  $o1.xopen_geometry_dependent("apical-non-trunk-list")
  $o1.xopen_geometry_dependent("oblique-paths")
  $o1.xopen_geometry_dependent("basal-paths")
  //$o1.xopen_geometry_dependent("superlinear-apical-tip-list")
  
  //sprint($o1.syscmd, "mv soma-list.eps axon-sec-list.eps %s", $o1.generic_dir)
  //system($o1.syscmd)
  //sprint($o1.syscmd, "mv apical-tip-list.eps  %s", $o1.generic_dir)
  //system($o1.syscmd)
  //sprint($o1.syscmd, "mv apical-tip-list-addendum.eps  %s", $o1.generic_dir)
  //system($o1.syscmd)
  //sprint($o1.syscmd, "mv apical-trunk-list.eps %s", $o1.generic_dir)
  //system($o1.syscmd)
  //sprint($o1.syscmd, "mv apical-non-trunk-list.eps %s", $o1.generic_dir)
  //system($o1.syscmd)
  //sprint($o1.syscmd, "mv basal-tree-list.eps %s", $o1.generic_dir)
  //system($o1.syscmd)

}










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