Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:147757
The role of amyloid beta (Aß) in brain function and in the pathogenesis of Alzheimer’s disease remains elusive. Recent publications reported that an increase in Aß concentration perturbs presynaptic release in hippocampal neurons, in particular by increasing release probability of CA3-CA1 synapses. The model predics how this alteration can affect synaptic plasticity and signal integration. The results suggest that the perturbation of release probability induced by increased Aß can significantly alter the spike probability of CA1 pyramidal neurons and thus contribute to abnormal hippocampal function during Alzheimer’s disease.
Reference:
1 . Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H (2013) Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Front Comput Neurosci 7:1 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Synaptic Integration; Aging/Alzheimer`s;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Romani, Armando [romani.armando -at- gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I M; I h; I Calcium; I_AHP; Glutamate;
/
RomaniEtAl2013
template
BasalPath.hoc *
ExperimentControl.hoc *
ObliquePath.hoc *
RangeRef.hoc *
                            
// This template creates the Basal Path lists, starting from the
// section attached to the trunk and ending with the basal tip section 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

begintemplate BasalPath

public basal_dtrunk_to_tip, basal_trunk_section, root_basal

strdef sexec

objref basal_trunk_section
strdef basal_trunk_section_name

objref root_basal
strdef root_basal_name

objref basal_tip_section
strdef basal_tip_section_name

objref basal_path

proc init () {
  sec_count=0

  forsec $o1 {

    if (sec_count==1) {
       root_basal    = new SectionRef()
       root_basal_name=secname()
    }
      
    if (!sec_count) {
       distance(0,1)
       basal_trunk_section  = new SectionRef()
       basal_trunk_section_name=secname()
      }
    sec_count=sec_count+1

    basal_tip_section    = new SectionRef()
    basal_tip_section_name=secname()
  }

  access root_basal.sec
  distance(0,0)
  access basal_tip_section.sec
  basal_dtrunk_to_tip=distance(1,1)

//printf("BasalPath basal_trunk_section: %s root_basal: %s basal_tip_section: %s distance between root_basal and basal_tip_section: %g\n", basal_trunk_section_name, root_basal_name, basal_tip_section_name, basal_dtrunk_to_tip)
}

endtemplate BasalPath

Loading data, please wait...