Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)

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Accession:147867
These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
Reference:
1 . Narayanan R, Chattarji S (2010) Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus. J Neurophysiol 103:3070-83 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Conductance distributions;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; AMPA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP; Glutamate;
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CA3Atrophy
Input
README.html
ampa.mod
borgkm.mod *
cadiv.mod *
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
h.mod
kad.mod
kahp.mod *
kap.mod
kdr.mod *
nahh.mod *
0.png
25.png
35.png
75.png
Fig1D.hoc
Fig2D-E.hoc
Fig2F-G.hoc
Menu.png
mosinit.hoc
neuron.que
Neurons.inp
                            
TITLE Borg-Graham K-M channel

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)

}

PARAMETER {
        cai (mM)
	v (mV)
        ek (mV)
	celsius 	(degC)
	gkmbar=.003 (mho/cm2)
        vhalf=-55   (mV)
        a0=0.006      (/ms)
        zeta=-10    (1)
        gm=0.06   (1)
        st=1
}


NEURON {
	SUFFIX borgkm
	USEION k READ ek WRITE ik
        RANGE gkmbar
        GLOBAL inf,tau
}

STATE {
        m
}

ASSIGNED {
	ik (mA/cm2)
        inf
        tau
}

INITIAL {
        rate(v)
        m=inf
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	ik = gkmbar*m^st*(v-ek)

}

FUNCTION alp(v(mV)) {
  alp = exp( 1.e-3*zeta*(v-vhalf)*9.648e4/(8.315*(273.16+celsius)))
}

FUNCTION bet(v(mV)) {
  bet = exp(1.e-3*zeta*gm*(v-vhalf)*9.648e4/(8.315*(273.16+celsius))) 
}

DERIVATIVE state {
        rate(v)
        m' = (inf - m)/tau
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,q10
        q10=5^((celsius-23)/10)
        a = alp(v)
        inf = 1/(1 + a)
        tau = bet(v)/(q10*a0*(1+a))
}
















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