Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)

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Accession:147867
These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
Reference:
1 . Narayanan R, Chattarji S (2010) Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus. J Neurophysiol 103:3070-83 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Conductance distributions;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; AMPA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP; Glutamate;
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CA3Atrophy
Input
README.html
ampa.mod
borgkm.mod *
cadiv.mod *
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
h.mod
kad.mod
kahp.mod *
kap.mod
kdr.mod *
nahh.mod *
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Fig1D.hoc
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Fig2F-G.hoc
Menu.png
mosinit.hoc
neuron.que
Neurons.inp
                            
TITLE nahh 
: From Traub & Miles "Neuronal networks of the hippocampus" (1991)
: but m^3 instead of m^2
NEURON {
	SUFFIX nahh
	USEION na READ ena WRITE ina
	RANGE gnabar
	GLOBAL inf,tau
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v (mV)
	celsius		(degC)
	gnabar=.300 	(mho/cm2)
	ena 		(mV)
}
STATE {
	m h
}
ASSIGNED {
	ina (mA/cm2)
	inf[2]
        tau[2]
}

INITIAL {
         mhn(v)
         m=inf[0]
         h=inf[1]
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	ina = gnabar*m*m*m*h*(v - ena)
}

DERIVATIVE states {	
	mhn(v*1(/mV))
	m' = (inf[0] - m)/tau[0]
	h' = (inf[1] - h)/tau[1]
}


FUNCTION alp(v(mV),i) { LOCAL q10 :  order m,h
        v=v+65
	q10 = 3^((celsius - 30)/10)
	if (i==0) {
		alp = q10*.32*expM1(13.1-v, 4)
	}else if (i==1){
		alp = q10*.128*exp((17-v)/18)
	}
}

FUNCTION bet(v,i) { LOCAL q10 : order m,h
        v=v+65
	q10 = 3^((celsius - 30)/10)
	if (i==0) {
		bet = q10*.28*expM1(v-40.1,5)
	}else if (i==1){
		bet = q10*4/(exp((40.0-v)/5) + 1)
	}
}

FUNCTION expM1(x,y) {
	if (fabs(x/y) < 1e-6) {
		expM1 = y*(1 - x/y/2)
	}else{
		expM1 = x/(exp(x/y) - 1)
	}
}

PROCEDURE mhn(v) {LOCAL a, b 
	FROM i=0 TO 1 {
		a = alp(v,i)  
		b=bet(v,i)
		tau[i] = 1/(a + b)
		inf[i] = a/(a + b)
	}
}


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