Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)

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Accession:148637
"… Recently, a lot of interest has been devoted to desynchronizing delayed feedback deep brain stimulation (DBS). ... This study explores the action of delayed feedback stimulation on partially synchronized oscillatory dynamics, similar to what one observes experimentally in parkinsonian patients. …" Implemented by Andrey Dovzhenok, to whom questions should be addressed.
Reference:
1 . Dovzhenok A, Park C, Worth RM, Rubchinsky LL (2013) Failure of delayed feedback deep brain stimulation for intermittent pathological synchronization in Parkinson's disease. PLoS One 8:e58264 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Subthalamus nucleus projection neuron; Globus pallidus neuron;
Channel(s): I Na,t; I T low threshold; I K; I_AHP; I Ca,p;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP; MATLAB;
Model Concept(s): Synchronization; Parkinson's; Deep brain stimulation;
Implementer(s): Dovzhenok, Andrey [andrey.dovzhenok at uc.edu];
Search NeuronDB for information about:  I Na,t; I T low threshold; I K; I_AHP; I Ca,p;
  
Reproduces figures 5 - 8 from

Dovzhenok, A., C. Park, R.M. Worth, L.L. Rubchinsky. 
Failure of delayed feedback deep brain stimulation for intermittent
pathological synchronization in Parkinson's disease.
PLoS One 8(3):e58264, 2013.

Implemented by Andrey Dovzhenok, to whom questions should be
addressed.

Usage:

1. Unzip Dovzhenoketal2013.zip into an empty directory.

2. Open the folder in Matlab.

3a. Run PCAgenerator1el.m to compute principal components for the
arrangement with a single electrode. The ode file with a single
electrode arrangement is used.
3b Run PCAgenerator.m to compute principal components for the
arrangements with two or three electrodes. Included ode-files
correspond to the various electrode arrangements considered in the
paper.  Specify the name of the ode-file corresponding to the desired
electrode arrangements on line 9 in odeFileName variable.

4a. Run Sign_subset_1el.m with the outcome of the step 3a to generate
figures 6A and 6B.
4b. Run Sign_subset.m with the outcome of the step 3b to generate
figure 5 and the rest of figure 6.

5a. Run Max_plane_1el.m with the outcomes of the step 3a to generate
figures 8A and 8B.
5b. Run Max_plane.m with the outcomes of the step 3b to generate
figure 7 and the rest of figure 8.

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