Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)

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Accession:148637
"… Recently, a lot of interest has been devoted to desynchronizing delayed feedback deep brain stimulation (DBS). ... This study explores the action of delayed feedback stimulation on partially synchronized oscillatory dynamics, similar to what one observes experimentally in parkinsonian patients. …" Implemented by Andrey Dovzhenok, to whom questions should be addressed.
Reference:
1 . Dovzhenok A, Park C, Worth RM, Rubchinsky LL (2013) Failure of delayed feedback deep brain stimulation for intermittent pathological synchronization in Parkinson's disease. PLoS One 8:e58264 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Subthalamus nucleus projection neuron; Globus pallidus neuron;
Channel(s): I Na,t; I T low threshold; I K; I_AHP; I Ca,p;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP; MATLAB;
Model Concept(s): Synchronization; Parkinson's; Deep brain stimulation;
Implementer(s): Dovzhenok, Andrey [andrey.dovzhenok at uc.edu];
Search NeuronDB for information about:  I Na,t; I T low threshold; I K; I_AHP; I Ca,p;
  
Reproduces figures 5 - 8 from

Dovzhenok, A., C. Park, R.M. Worth, L.L. Rubchinsky. 
Failure of delayed feedback deep brain stimulation for intermittent
pathological synchronization in Parkinson's disease.
PLoS One 8(3):e58264, 2013.

Implemented by Andrey Dovzhenok, to whom questions should be
addressed.

Usage:

1. Unzip Dovzhenoketal2013.zip into an empty directory.

2. Open the folder in Matlab.

3a. Run PCAgenerator1el.m to compute principal components for the
arrangement with a single electrode. The ode file with a single
electrode arrangement is used.
3b Run PCAgenerator.m to compute principal components for the
arrangements with two or three electrodes. Included ode-files
correspond to the various electrode arrangements considered in the
paper.  Specify the name of the ode-file corresponding to the desired
electrode arrangements on line 9 in odeFileName variable.

4a. Run Sign_subset_1el.m with the outcome of the step 3a to generate
figures 6A and 6B.
4b. Run Sign_subset.m with the outcome of the step 3b to generate
figure 5 and the rest of figure 6.

5a. Run Max_plane_1el.m with the outcomes of the step 3a to generate
figures 8A and 8B.
5b. Run Max_plane.m with the outcomes of the step 3b to generate
figure 7 and the rest of figure 8.

Dovzhenok A, Park C, Worth RM, Rubchinsky LL (2013) Failure of delayed feedback deep brain stimulation for intermittent pathological synchronization in Parkinson's disease. PLoS One 8:e58264[PubMed]

References and models cited by this paper

References and models that cite this paper

External trial deep brain stimulation device for the application of desynchronizing stimulation techniques. J Neural Eng 6:066003-16 [PubMed]

Ahn S, Park C, Rubchinsky LL (2011) Detecting the temporal structure of intermittent phase locking. Phys Rev E Stat Nonlin Soft Matter Phys 84:016201-14

Appleby BS, Duggan PS, Regenberg A, Rabins PV (2007) Psychiatric and neuropsychiatric adverse events associated with deep brain stimulation: A meta-analysis of ten years' experience. Mov Disord 22:1722-8 [PubMed]

Best J, Park C, Terman D, Wilson C (2007) Transitions between irregular and rhythmic firing patterns in excitatory-inhibitory neuronal networks. J Comput Neurosci 23:217-35 [Journal] [PubMed]

Bevan MD, Magill PJ, Terman D, Bolam JP, Wilson CJ (2002) Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network. Trends Neurosci 25:525-31 [PubMed]

Brown P (2007) Abnormal oscillatory synchronisation in the motor system leads to impaired movement. Curr Opin Neurobiol 17:656-64 [PubMed]

Dorval AD, Russo GS, Hashimoto T, Xu W, Grill WM, Vitek JL (2008) Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson's disease. J Neurophysiol 100:2807-18 [PubMed]

Eusebio A, Brown P (2009) Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? Exp Neurol 217:1-3 [PubMed]

Grill WM, Snyder AN, Miocinovic S (2004) Deep brain stimulation creates an informational lesion of the stimulated nucleus. Neuroreport 15:1137-40 [PubMed]

Guo Y, Rubin JE (2011) Multi-site stimulation of subthalamic nucleus diminishes thalamocortical relay errors in a biophysical network model. Neural Netw 24:602-16 [PubMed]

Hahn PJ, Russo GS, Hashimoto T, Miocinovic S, Xu W, McIntyre CC, Vitek JL (2008) Pallidal burst activity during therapeutic deep brain stimulation. Exp Neurol 211:243-51 [PubMed]

Hammond C, Bergman H, Brown P (2007) Pathological synchronization in Parkinson's disease: networks, models and treatments. Trends Neurosci 30:357-64 [PubMed]

Hashimoto T, Elder CM, Okun MS, Patrick SK, Vitek JL (2003) Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons. J Neurosci 23:1916-23 [PubMed]

Hauptmann C, Tass PA (2010) Restoration of segregated, physiological neuronal connectivity by desynchronizing stimulation. J Neural Eng 7:056008-346 [PubMed]

Hurtado JM, Rubchinsky LL, Sigvardt KA, Wheelock VL, Pappas CT (2005) Temporal evolution of oscillations and synchrony in GPi-muscle pairs in Parkinson's disease. J Neurophysiol 93:1569-84 [PubMed]

Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ (2007) Translational principles of deep brain stimulation. Nat Rev Neurosci 8:623-35 [PubMed]

Lozano AM, Dostrovsky J, Chen R, Ashby P (2002) Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neurol 1:225-31 [PubMed]

Mallet N, Pogosyan A, Marton LF, Bolam JP, Brown P, Magill PJ (2008) Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity. J Neurosci 28:14245-58 [PubMed]

McIntyre CC, Mori S, Sherman DL, Thakor NV, Vitek JL (2004) Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Clin Neurophysiol 115:589-95 [PubMed]

Park C, Rubchinsky LL (2011) Intermittent synchronization in a network of bursting neurons. Chaos 21:033125-14

Park C, Worth RM, Rubchinsky LL (2010) Fine temporal structure of beta oscillations synchronization in subthalamic nucleus in Parkinson's disease. J Neurophysiol 103:2707-16 [PubMed]

Park C, Worth RM, Rubchinsky LL (2011) Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics. Phys Rev E Stat Nonlin Soft Matter Phys 83:042901-14

Pessiglione M, Guehl D, Rolland AS, François C, Hirsch EC, Feger J, Tremblay L (2005) Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuits. J Neurosci 25:1523-31 [PubMed]

Popovych OV, Hauptmann C, Tass PA (2005) Effective desynchronization by nonlinear delayed feedback. Phys Rev Lett 94:164102-31 [PubMed]

Popovych OV, Hauptmann C, Tass PA (2006) Control of neuronal synchrony by nonlinear delayed feedback. Biol Cybern 95:69-85 [PubMed]

Popovych OV, Tass PA (2010) Synchronization control of interacting oscillatory ensembles by mixed nonlinear delayed feedback. Phys Rev E Stat Nonlin Soft Matter Phys 82:026204-14

Rosenblum M, Pikovsky A (2004) Delayed feedback control of collective synchrony: an approach to suppression of pathological brain rhythms. Phys Rev E Stat Nonlin Soft Matter Phys 70:041904

Rosenblum M, Tukhlina N, Pikovsky A, Cimponeriu L (2006) Delayed Feedback Suppression of Collective Rhythmic Activity in a Neuronal Ensemble Int J Bifurcation And Chaos 16:1989-1999

Rosenblum MG, Pikovsky AS (2004) Controlling synchronization in an ensemble of globally coupled oscillators. Phys Rev Lett 92:114102-31 [PubMed]

Rubchinsky LL, Park C, Worth RM (2012) Intermittent neural synchronization in Parkinson's disease. Nonlinear Dyn 68:329-346 [PubMed]

Sannita WG (2008) Neuronal functional diversity and collective behaviors. J Biol Phys 34:267-78 [PubMed]

Schiff SJ (2010) Towards model-based control of Parkinson's disease. Philos Transact A Math Phys Eng Sci 368:2269-308 [PubMed]

Schnitzler A, Gross J (2005) Normal and pathological oscillatory communication in the brain. Nat Rev Neurosci 6:285-96 [PubMed]

Terman D, Rubin JE, Yew AC, Wilson CJ (2002) Activity patterns in a model for the subthalamopallidal network of the basal ganglia. J Neurosci 22:2963-76 [Journal] [PubMed]

   Optimal deep brain stimulation of the subthalamic nucleus-a computational study (Feng et al. 2007) [Model]

Tukhlina N, Rosenblum M (2008) Feedback suppression of neural synchrony in two interacting populations by vanishing stimulation. J Biol Phys 34:301-14

Tukhlina N, Rosenblum M, Pikovsky A, Kurths J (2007) Feedback suppression of neural synchrony by vanishing stimulation. Phys Rev E Stat Nonlin Soft Matter Phys 75:011918

Uhlhaas PJ, Singer W (2006) Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 52:155-68 [PubMed]

Umemura A, Jaggi JL, Hurtig HI, Siderowf AD, Colcher A, Stern MB, Baltuch GH (2003) Deep brain stimulation for movement disorders: morbidity and mortality in 109 patients. J Neurosurg 98:779-84 [PubMed]

Wichmann T, Delong MR (2006) Deep brain stimulation for neurologic and neuropsychiatric disorders. Neuron 52:197-204 [PubMed]

Wingeier B, Tcheng T, Koop MM, Hill BC, Heit G, Bronte-Stewart HM (2006) Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease. Exp Neurol 197:244-51 [PubMed]

Wongsarnpigoon A, Grill WM (2010) Energy-efficient waveform shapes for neural stimulation revealed with a genetic algorithm. J Neural Eng 7:046009-346 [PubMed]

Kerr CC, Van Albada SJ, Neymotin SA, Chadderdon GL, Robinson PA, Lytton WW (2013) Cortical information flow in Parkinson's disease: a composite network-field model. Front Comput Neurosci 7:39:1-14 [Journal] [PubMed]

   Composite spiking network/neural field model of Parkinsons (Kerr et al 2013) [Model]

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