Using Strahler`s analysis to reduce realistic models (Marasco et al, 2013)

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Building on our previous work (Marasco et al., (2012)), we present a general reduction method based on Strahler's analysis of neuron morphologies. We show that, without any fitting or tuning procedures, it is possible to map any morphologically and biophysically accurate neuron model into an equivalent reduced version. Using this method for Purkinje cells, we demonstrate how run times can be reduced up to 200-fold, while accurately taking into account the effects of arbitrarily located and activated synaptic inputs.
1 . Marasco A, Limongiello A, Migliore M (2013) Using Strahler`s analysis to reduce up to 200-fold the run time of realistic neuron model Sci. Rep. 3:2934 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Hippocampus; Cerebellum;
Cell Type(s): Hippocampus CA1 pyramidal cell; Cerebellum purkinje cell;
Channel(s): I Na,t; I T low threshold; I K; I Calcium; Ca pump;
Gap Junctions:
Receptor(s): AMPA;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Synaptic Integration;
Implementer(s): Limongiello, Alessandro [alessandro.limongiello at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Cerebellum purkinje cell; AMPA; I Na,t; I T low threshold; I K; I Calcium; Ca pump; Glutamate;
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ranstream.hoc *
NEURON files from the paper:

Using Strahler�s analysis to reduce up to 200-fold the run time 
of realistic neuron models, by A. Marasco, A.Limongiello, and M.Migliore
(2013) Sci. Rep. 3, 2934; DOI:10.1038/srep02934 (in press).


Compile the mod files and run RedPurk.hoc for the main simulation

The simulation file allows to play with the different morphologies used in the paper.

Example run: After the simulation starts press the "Run the Full &
Reduced Models" button, then select e4cb3a1.hoc in the morphologies
folder. The simulation will reproduce the traces in Fig.2D (left) of
the paper (where the last 1000 ms are shown). 

Questions on the code should be addressed to 
Alessandro Limongiello:

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