Roles of essential kinases in induction of late hippocampal LTP (Smolen et al., 2006)

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Accession:149175
"… Convergence of multiple kinase activities to induce L-LTP helps to generate a threshold whereby the amount of L-LTP varies steeply with the number of brief (tetanic) electrical stimuli. The model simulates tetanic, -burst, pairing-induced, and chemical L-LTP, as well as L-LTP due to synaptic tagging. The model also simulates inhibition of L-LTP by inhibition of MAPK, CAMKII, PKA, or CAMKIV. The model predicts results of experiments to delineate mechanisms underlying L-LTP induction and expression. …"
Reference:
1 . Smolen P, Baxter DA, Byrne JH (2006) A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J 90:2760-75 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: Java;
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; CREB;
Implementer(s): Byrne, John [john.h.byrne at uth.tmc.edu]; Smolen, Paul [paul.d.smolen at uth.tmc.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; NMDA; Glutamate;
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Smolen_LTP_2006
readme.txt
smolenltp.java
                            
The accompanying Java model file, smolenltp.java, runs tetanic,
theta-burst, and chemical late LTP simulations from

Smolen P, Baxter DA, Byrne JH (2006). A model of the roles of
essential kinases in the induction and expression of late long-term
potentiation.  Biophys J. 90(8):2760-75.

To compile and run this file, save as smolenltp.java. Then with java
compiler installed (e.g. JDK from Oracle), type "javac smolenltp.java"
to compile and "java smolenltp" to run. Output will be ASCII 2-column
text files which reproduces figures 3 - 6 of the paper.  The
PrintWriter statements at the start of the program give the names of
these files, they can be altered at will.

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