Olfactory Computations in Mitral-Granule cell circuits (Migliore & McTavish 2013)

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Accession:149415
Model files for the entry "Olfactory Computations in Mitral-Granule Cell Circuits" of the Springer Encyclopedia of Computational Neuroscience by Michele Migliore and Tom Mctavish. The simulations illustrate two typical Mitral-Granule cell circuits in the olfactory bulb of vertebrates: distance-independent lateral inhibition and gating effects.
Reference:
1 . Migliore M, McTavish T (2013) Olfactory Computation in Mitral-Granule Cell Circuits Encyclopedia of Computational Neuroscience, Jaeger D, Jung R, ed.
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Intrinsic plasticity; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell; AMPA; NMDA; Gaba; I Na,t; I A; I K; Gaba; Glutamate;
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MiglioreMcTavish2013
readme.html
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanetOB.mod *
forfig1-springer.hoc
forfig2.ses
forfig2-springer.hoc
forfig3-springer.hoc
gc-ka.hoc
mitral-lss.hoc
mosinit.hoc
screenshot1.png
screenshot2.png
screenshot3.png
                            
TITLE K-DR
: K-DR current for Mitral Cells from Wang et al (1996)
: M.Migliore Jan. 2002

NEURON {
	SUFFIX kdrmt
	USEION k READ ek WRITE ik
	RANGE  gbar
	GLOBAL minf, mtau
}

PARAMETER {
	gbar = 0.002   	(mho/cm2)	
								
	celsius
	ek		(mV)            : must be explicitly def. in hoc
	v 		(mV)
	a0m=0.0035
	vhalfm=-50
	zetam=0.055
	gmm=0.5

	q10=3
}


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

ASSIGNED {
	ik 		(mA/cm2)
	minf 		mtau (ms)	 	
}
 

STATE { m}

BREAKPOINT {
        SOLVE states METHOD cnexp
	ik = gbar*m*(v - ek)
} 

INITIAL {
	trates(v)
	m=minf  
}

DERIVATIVE states {   
        trates(v)      
        m' = (minf-m)/mtau
}

PROCEDURE trates(v) {  
	LOCAL qt
        qt=q10^((celsius-24)/10)
        minf = 1/(1 + exp(-(v-21)/10))
	mtau = betm(v)/(qt*a0m*(1+alpm(v)))
}

FUNCTION alpm(v(mV)) {
  alpm = exp(zetam*(v-vhalfm)) 
}

FUNCTION betm(v(mV)) {
  betm = exp(zetam*gmm*(v-vhalfm)) 
}

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