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A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
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This is a two-layer biophysical olfactory bulb (OB) network model to study cholinergic neuromodulation. Simulations show that nicotinic receptor activation sharpens mitral cell receptive field, while muscarinic receptor activation enhances network synchrony and gamma oscillations. This general model suggests that the roles of nicotinic and muscarinic receptors in OB are both distinct and complementary to one another, together regulating the effects of ascending cholinergic inputs on olfactory bulb transformations.
Li G, Cleland TA (2013) A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.
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Olfactory bulb main mitral GLU cell;
Olfactory bulb main interneuron periglomerular GABA cell;
Olfactory bulb main interneuron granule MC GABA cell;
I L high threshold;
I T low threshold;
I Cl, leak;
Li, Guoshi [guoshi_li at med.unc.edu];
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Olfactory bulb main mitral GLU cell
Olfactory bulb main interneuron periglomerular GABA cell
Olfactory bulb main interneuron granule MC GABA cell
I L high threshold
I T low threshold
I Cl, leak
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