KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)

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Accession:150024
The output of the cerebellum to the motor axis of the central nervous system is orchestrated mainly by synaptic inputs and intrinsic pacemaker activity of deep cerebellar nuclear (DCN) projection neurons. Herein, we demonstrate that the soma of these cells is enriched with KV1 channels produced by mandatory multi-merization of KV1.1, 1.2 alpha andKV beta2 subunits. Being constitutively active, the K+ current (IKV1) mediated by these channels stabilizes the rate and regulates the temporal precision of self-sustained firing of these neurons. ... Through the use of multi-compartmental modelling and ... the physiological significance of the described functions for processing and communication of information from the lateral DCN to thalamic relay nuclei is established.
Reference:
1 . Ovsepian SV, Steuber V, Le Berre M, O`Hara L, O`Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol 591:1771-91 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum deep nucleus neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Kv1.1 KCNA1; Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Intrinsic plasticity; Rebound firing;
Implementer(s): Steuber, Volker [v.steuber at herts.ac.uk]; Luthman, Johannes [jwluthman at gmail.com];
Search NeuronDB for information about:  AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
/
CNModel_May2013
readme.txt
CaConc.mod *
CaHVA.mod *
CalConc.mod *
CaLVA.mod *
DCNsyn.mod *
DCNsynGABA.mod *
DCNsynNMDA.mod *
fKdr.mod *
GammaStim.mod *
h.mod *
Ifluct8.mod *
NaF.mod *
NaP.mod *
pasDCN.mod *
SK.mod *
sKdr.mod *
TNC.mod *
DCN_cip_axis_main.hoc
DCN_cip_fi_main.hoc
DCN_mechs1.hoc *
DCN_mechs2.hoc
DCN_morph.hoc *
DCN_params.hoc
DCN_params_axis.hoc
DCN_params_fi_init.hoc
DCN_params_rebound.hoc
DCN_rebound_main.hoc
DCN_recording.hoc
DCN_spontact_loop_main.hoc
                            
This is the readme for the model associated with the paper:

Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO
(2013) A defined heteromeric KV1 channel stabilizes the intrinsic
pacemaking and regulates the output of deep cerebellar nuclear neurons
to thalamic targets. J Physiol 591:1771-91

This model was contributed by Dr Volker Steuber.  The computer code
was written in NEURON which is freely available at
http://www.neuron.yale.edu

Use: auto-launch from ModelDB or download, extract, and compile the
mod files with the "nrnivmodl" command after cd'ing to the extracted
folder (linux/unix), or drag and drop the folder on the mknrndll icon
(Mac OS X), or cd'ing to the folder with mknrndll (mswin). Start the
simulation by pressing return a couple times (during autolaunch to
compile and start), drag and drop one of the below files on the nrngui
icon (Mac OS X), or double clicking one of the below files (mswin).

The following scripts replicate figures in Ovsepian et al. (2013)

Fig 9A,B: DCN_spontact_loop_main.hoc
Fig 9C,D: DCN_rebound_main.hoc
Fig 9E: DCN_cip_fi_main.hoc
Fig 9F: DCN_cip_axis_main.hoc

They each produce the appropriate data files and then exit.  Note that
DCN_cip_axis_main.hoc takes just a few minutes so if you want a quick
demo try that instead of the longer scripts.

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