MEC layer II stellate cell: Synaptic mechanisms of grid cells (Schmidt-Hieber & Hausser 2013)

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Accession:150239
This study investigates the cellular mechanisms of grid field generation in Medial Entorhinal Cortex (MEC) layer II stellate cells.
Reference:
1 . Schmidt-Hieber C, Häusser M (2013) Cellular mechanisms of spatial navigation in the medial entorhinal cortex. Nat Neurosci 16:325-31 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s): Entorhinal cortex stellate cell;
Channel(s): I Na,t; I A; I K; I CNG;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Synaptic Integration; Attractor Neural Network; Place cell/field; Spatial Navigation; Grid cell;
Implementer(s): Schmidt-Hieber, Christoph [c.schmidt-hieber at ucl.ac.uk];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Gaba; I Na,t; I A; I K; I CNG;
COMMENT
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from ModelDB:

Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) 
Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel 
beta Subunits via Paradoxical Effects on Persistent Sodium Currents. J Neurosci 30:8489-501 

as used by
Welday AC, Shlifer IG, Bloom ML, Zhang K, Blair HT (2011) 
Cosine Directional Tuning of Theta Cell Burst Frequencies:
Evidence for Spatial Coding by Oscillatory Interference.
J. Neurosci. 31:16157-16176
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ENDCOMMENT

TITLE nap

NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
	RANGE  gbar, thegna, sh, scalerate
	: GLOBAL minf, mtau 
	:, hinf, mtau, htau
}

PARAMETER {
	gbar = .0052085   	(mho/cm2)
	sh = 0  (mV)
	eNa = 55 	(mV)
	scalerate = 1	(ms)	
	ena		(mV)            
	celsius (degC)
	v 		(mV)
}


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

ASSIGNED {
	ina 		(mA/cm2)
	thegna		(mho/cm2)
	minf 	
	mtau (ms)
}
 

STATE { m }

UNITSOFF

BREAKPOINT {
    SOLVE states METHOD cnexp
	        		
	thegna =gbar*m       
	ina = thegna * (v - eNa)
	} 

INITIAL {
	mtau = scalerate
	minf = (1/(1+exp(-(v+52.3-sh)/6.8)))      	
	m=minf  
	
}

DERIVATIVE states {   
    
	mtau = scalerate
	minf = (1/(1+exp(-(v+52.3-sh)/6.8))) 	         	
	m' = (minf-m)/mtau
}



UNITSON

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