A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)

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Accession:150288
1000 Cell Lateral Amygdala model for investigation of plasticity and memory storage during Pavlovian Conditioning.
Reference:
1 . Kim D, Paré D, Nair SS (2013) Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdala. Learn Mem 20:421-30 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism: Amygdala;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hodgkin-Huxley neuron;
Channel(s): I Na,t; I L high threshold; I A; I M; I Sodium; I Calcium; I Potassium; I_AHP; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba; Dopaminergic Receptor;
Gene(s):
Transmitter(s): Dopamine; Norephinephrine;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Long-term Synaptic Plasticity; Learning; Neuromodulation;
Implementer(s): Kim, Dongbeom [dk258 at mail.missouri.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; AMPA; NMDA; Gaba; Dopaminergic Receptor; I Na,t; I L high threshold; I A; I M; I Sodium; I Calcium; I Potassium; I_AHP; Ca pump; Dopamine; Norephinephrine;
/
KimEtAl2013
README.txt
bg2inter.mod
bg2pyr.mod
ca.mod *
cadyn.mod
cal2.mod *
capool.mod *
function_TMonitor.mod *
h.mod *
im.mod
interD2pyrD_STFD.mod
interD2pyrDDA_STFD.mod
interD2pyrDDANE_STFD.mod
interD2pyrDNE_STFD.mod
interD2pyrV_STFD.mod
interD2pyrVDA_STFD.mod
interV2pyrD_STFD.mod
interV2pyrDDA_STFD.mod
interV2pyrDDANE_STFD.mod
interV2pyrDNE_STFD.mod
interV2pyrV_STFD.mod
interV2pyrVDA_STFD.mod
kadist.mod *
kaprox.mod
kdrca1.mod
kdrca1DA.mod
kdrinter.mod *
leak.mod *
leakDA.mod *
leakinter.mod *
na3.mod
na3DA.mod
nainter.mod *
pyrD2interD_STFD.mod
pyrD2interV_STFD.mod
pyrD2pyrD_STFD.mod
pyrD2pyrDDA_STFD.mod
pyrD2pyrV_STFD.mod
pyrD2pyrVDA_STFD.mod
pyrV2interD_STFD.mod
pyrV2interV_STFD.mod
pyrV2pyrD_STFD.mod
pyrV2pyrDDA_STFD.mod
pyrV2pyrV_STFD.mod
pyrV2pyrVDA_STFD.mod
sahp.mod
sahpNE.mod
shock2interD.mod
shock2interV.mod
shock2pyrD.mod
shock2pyrV.mod
tone2interD.mod
tone2interDNE.mod
tone2interV.mod
tone2interVNE.mod
tone2pyrD.mod
tone2pyrD_LAdv.mod
tone2pyrDNE.mod
tone2pyrDNE_LAdv.mod
tone2pyrV.mod
tone2pyrV_LAdd.mod
tone2pyrVNE.mod
tone2pyrVNE_LAdd.mod
BgGen.hoc
Cell_list.txt
Cell_type.txt
function_ConnectInternal.hoc
function_ConnectTwoCells.hoc
function_NetStimOR.hoc *
function_TimeMonitor.hoc *
function_ToneGen.hoc
function_ToneSignalGen_Ctx.hoc
function_ToneSignalGen_Th.hoc
interneuron_template.hoc
LA_model_main_file.hoc
LAcells_template.hoc
NM.txt
shock2Idd.txt
shock2Idv.txt
shock2LAdd.txt
shock2LAdv.txt
shockcondi.hoc
Syn_Matrix.txt
tone2Idd.txt
tone2Idd2.txt
tone2Idv.txt
tone2Idv2.txt
tone2LAdd.txt
tone2LAdd2.txt
tone2LAdv.txt
tone2LAdv2.txt
                            
/////////////////////
// Model Templates //
/////////////////////

begintemplate InterneuronCell
	public soma, dend, connect2target, type
	create soma, dend

	public ncl, synlist
	objref ncl, synlist
	strdef type

	proc init() {
		synlist = new List()
		ncl = new List()
		type = "InterneuronCell"

		/////// topology ////////
		create soma, dend
		connect dend(0), soma(1)

		/////// geometry ////////
		soma {
			nseg=1
			L=15		// (micrometer)
			diam=15		// (micrometer)
	    	}

		dend {
			nseg=1
			L=150		// (micrometer)
			diam=10		// (micrometer)
		}

		/////// biophysics //////
		soma {
			cm = 1		    // (microF/cm2)
			Ra = 150*22.5	// (ohm-cm)
			Rm = 20000	    // (ohm-cm2)
			
			insert leakinter
			glbar_inter_leakinter = 1/Rm // (siemens/cm2)
			el_leakinter = -70	// (mV)

			insert nainter
			insert kdrinter
	    	}

		dend {
			cm = 1		// (microF/cm2)
			Ra = 150	// (ohm-cm)
			Rm = 20000	// (ohm-cm2)
			
			insert leakinter
			glbar_inter_leakinter = 1/Rm // (siemens/cm2)
			el_leakinter = -70	// (mV)

			insert nainter
			insert kdrinter
		}
		soma {
			ena = 45		// (mV)
			gnabar_nainter = 0.035	// (siemens/cm2)

			ek = -80		// (mV)
			gkdrbar_kdrinter = 0.008 // (siemens/cm2)
			
		}

		dend {
			ena = 45		// (mV)
			gnabar_nainter = 0.010	// (siemens/cm2)

			ek = -80		// (mV)
			gkdrbar_kdrinter = 0.003 // (siemens/cm2)
			
			insert ca_ion
			eca = 120
		}
	}

obfunc connect2target() { localobj nc
	soma nc = new NetCon(&v(0.5), $o1)
	nc.threshold = 0
	if (numarg() == 2) ($o2 = nc)
	return nc
	}
endtemplate InterneuronCell

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