L5 pyr. cell spiking control by oscillatory inhibition in distal apical dendrites (Li et al 2013)

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Accession:150538
This model examined how distal oscillatory inhibition influences the firing of a biophysically-detailed layer 5 pyramidal neuron model.
Reference:
1 . Li X, Morita K, Robinson HP, Small M (2013) Control of layer 5 pyramidal cell spiking by oscillatory inhibition in the distal apical dendrites: a computational modelling study. J Neurophysiol 109(11):2739-2756 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s): I K,Ca; I Na, leak;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Moradi, Keivan [k.moradi at gmail.com]; Robinson, H.P.C. [hpcr at cam.ac.uk]; Small, Michael ; Li, Xiumin ;
Search NeuronDB for information about:  AMPA; I K,Ca; I Na, leak; Dopamine;
/
XiEtal2013
Codes for periodic inhibition
ReadMe.txt
cad2.mod
GABABsyn.mod
h.mod
kca.mod *
km.mod *
kv.mod *
na.mod *
NMDAr.mod
SlowCa.mod *
basal_soma_periodicgaba_stimulus.hoc
basal_soma_Poissongaba_stimulus.hoc
distal_distributed_periodic_gaba_stimulus.hoc
distal_distributed_periodic_gaba+gabab_stimulus.hoc
distal_distributed_Poisson_gaba_stimulus.hoc
distal_distributed_Poisson_GABAb_stimulus.hoc
j4a.hoc *
mainfile_stim_cyc.hoc
mosinit.hoc
                            
This is the readme for the model associated with the paper

X. Li, K. Morita, H. P. C. Robinson and M. Small (2013) Control of
layer 5 pyramidal cell spiking by oscillatory inhibition in the distal
apical dendrites: a computational modelling study. J Neurophysiol.


General description of the model:

This model examined how distal oscillatory inhibition influences the
firing of a biophysically-detailed layer 5 pyramidal neuron model.


Running the file "mainfile_stim_cyc.hoc" will start the simulation
with the most typical configuration. Compile the mod files first with
mknrndll (MAC and mswin) if starting manually.


Description of key files:

"j4a.hoc" defines the model of a layer 5 pyramidal neuron from the
paper of Mainen Nature 1996.

The other hoc files define different distributions of GLUT and GABA
synapses over the soma, basal and distal dendrites.

The Matlab files i.e. "makestim_GABAgamma_stim.m" are used to generate
the oscillatory inhibitory inputs at different frequencies.

20150525 Update from Ted Carnevale: Fixed ca initialization by
inserting cai = ca into INITIAL block.  Changed integration method
from euler to derivimplicit which is appropriate for simple ion
accumulation mechanisms.  See Integration methods for SOLVE statements
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592

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