Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:150556
A biophysical single compartment model of the dorsal lateral striatum medium spiny neuron is presented here. The model is an implementation then adaptation of a previously described model (Mahon et al. 2002). The model has been adapted to include NMDA and AMPA receptor models that have been fit to dorsal lateral striatal neurons. The receptor models allow for excitation by other neuron models.
Reference:
1 . Biddell K, Johnson J (2013) A Biophysical Model of Cortical Glutamate Excitation of Medium Spiny Neurons in the Dorsal Lateral Striatum 56th IEEE Midwest Symposium on Circuits and Systems
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Connectionist Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum spiny neuron;
Channel(s): I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Short-term Synaptic Plasticity; Parkinson's; Learning; Deep brain stimulation; Olfaction;
Implementer(s): Biddell, Kevin [kevin.biddell at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; AMPA; NMDA; I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak; Glutamate;
TITLE Leakm current
:NOTE 1S=1mho Neuron wants the units in mhos not millisiemens, please not the conversion! 
UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}
 
NEURON {
        SUFFIX Leakm
        NONSPECIFIC_CURRENT il
        RANGE  gl, el
}
 
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
 
PARAMETER {
       
        gl = .00001 (mho/cm2) : changed from 0.075 mS by KMB
        el = -75 (mV)
}
  
ASSIGNED {
	 v (mV)
        il (mA/cm2)
}
 
BREAKPOINT {
:        SOLVE states
        il = gl*(v - el)
}
 

Loading data, please wait...