Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)

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Accession:150556
A biophysical single compartment model of the dorsal lateral striatum medium spiny neuron is presented here. The model is an implementation then adaptation of a previously described model (Mahon et al. 2002). The model has been adapted to include NMDA and AMPA receptor models that have been fit to dorsal lateral striatal neurons. The receptor models allow for excitation by other neuron models.
Reference:
1 . Biddell K, Johnson J (2013) A Biophysical Model of Cortical Glutamate Excitation of Medium Spiny Neurons in the Dorsal Lateral Striatum 56th IEEE Midwest Symposium on Circuits and Systems
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Connectionist Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum spiny neuron;
Channel(s): I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Short-term Synaptic Plasticity; Parkinson's; Learning; Deep brain stimulation; Olfaction;
Implementer(s): Biddell, Kevin [kevin.biddell at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; AMPA; NMDA; I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak; Glutamate;
//----------------------------------------------------------------------------
access str_soma
objectvar stim2,upbkgrnd,dwnbkgrnd // insert NetStim in MSN neuron Changed 3/28/2012 KMB From stim1
 

//create "artificial cell" stimulation
//***********************************************************************************

proc cor_stim() { 
		


objref stim2,upbkgrnd,dwnbkgrnd


		//To excite in the upstate Amplitude does not make the difference frequecy does
		// the upstate peak is ~800 Hz with max upstate lasting ~300ms Blackwell et al 2003
		// to keep the cell in up state the input must be at least 450 hz for no more than 300ms
		// This is the Glutamate connection i.e. NMDA AMPA stimulation
		
		stim2 = new KBNetStim(0.5) //3/28/2012 KMB Changed to add functionality to NetStim
		stim2.interval = 2	// therefore interval should be ~3.333msec
		// With upstate background at 2 ms interval (500 hz) this should cause excitation
		stim2.number = 0
		stim2.noise = 0
		stim2.start = 1
		

		//interval therefore should not chage only number if the upstate bckground noise 
		//is 500Hz to cause firing it should increase up to ~800 therefor add 300Hz input
		
		//This is an upstate background it is 
		
		// Therefore 150 pulses with interval of 2.0 ms= 300 ms w/ f=500 Hz

		
		upbkgrnd = new KBNetStim(0.5) //3/28/2012 KMB Changed to add functionality to NetStim
		upbkgrnd.interval = 2.5		
		upbkgrnd.number = 13			//(msec)interval*number = time
		upbkgrnd.noise = 0
		upbkgrnd.start = 1
		
		dwnbkgrnd = new KBNetStim(0.5) //3/28/2012 KMB Changed to add functionality to NetStim
		
		
		// for down state ~ 300 seems to be accurate 
		
		dwnbkgrnd.interval =25		 // for down state ~10-40Hz this is 100ms to 25ms 
		dwnbkgrnd.number =0			// (msec) interval*number = time
		dwnbkgrnd.noise =0		
		dwnbkgrnd.start =1
		
		
}
		

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