Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)

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Accession:150556
A biophysical single compartment model of the dorsal lateral striatum medium spiny neuron is presented here. The model is an implementation then adaptation of a previously described model (Mahon et al. 2002). The model has been adapted to include NMDA and AMPA receptor models that have been fit to dorsal lateral striatal neurons. The receptor models allow for excitation by other neuron models.
Reference:
1 . Biddell K, Johnson J (2013) A Biophysical Model of Cortical Glutamate Excitation of Medium Spiny Neurons in the Dorsal Lateral Striatum 56th IEEE Midwest Symposium on Circuits and Systems
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Connectionist Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny neuron;
Channel(s): I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Short-term Synaptic Plasticity; Parkinson's; Learning; Deep brain stimulation; Olfaction;
Implementer(s): Biddell, Kevin [kevin.biddell at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; AMPA; NMDA; I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak; Glutamate;
//This is a MSN model as implemented by Kevin Biddell
// all questions should be directed to Kevin at kevin.biddell@gmail.com

//Created by Kevin Biddell
//4/18/07
load_file("nrngui.hoc")

celsius =37 //Wickens and Wilson 1998 OK
tstop = 150
	
create str_soma 
access str_soma
load_file("cortical_stimulation.hoc") 
load_file("injection_stimulation.hoc")
//load_file("ComplexRun.ses")	//Added KMB 3/28/2012
str_soma{

      nseg = 3
	diam= 18	
      	L = 11	// KMB approximation of size of real striatal neuron of wickens and Wilson 1998 
	insert Nam
	insert Km
	insert Leakm
	insert Kirm
	insert KAfm
	insert KAsm
	insert Krpm
	insert NaPm
	insert NaSm
	
	I_stim() // ran to excite/stimulate the cell by way of current injection
	cor_stim() // ran to excite/stimulate the cell by way of cortex
	
}

//----------------------------------------------------------------------------
//  insert postsynaptic mechansisms ie NMDA and AMPA channels developed from Wolf et al
//----------------------------------------------------------------------------

//_______NMDAw______________________________________________

objectvar strNMDAk
strNMDAk = new NMDAk()          // create synapse
str_soma strNMDAk.loc(0.4)         // assign postsynaptic compartment


//_________AMPAw_________________________________________

objectvar strAMPAk
strAMPAk = new AMPAk()          // create post synapse
str_soma strAMPAk.loc(0.5)         // assign postsynaptic compartment

objref NMDAcon, AMPAcon, GluCon1,GluCon2,GluCon3,GluCon4
//direct inputs theoretically should be the same synaptic strength, frequency of input is the cause of depolarization
NMDAcon = new NetCon(stim2,strNMDAk,0.1,1,1) //connection between artificial cells & channels
AMPAcon = new NetCon(stim2,strAMPAk,0.1,1,1) //connection between artificial cells & channels
//4.14.13 KMB changed the weights of the background stimulation to 0.8 from 1
GluCon1 = new NetCon(dwnbkgrnd,strNMDAk,0.1,1,0.8)
GluCon2 = new NetCon(dwnbkgrnd,strAMPAk,0.1,1,0.8)
GluCon3 = new NetCon(upbkgrnd,strNMDAk,0.1,1,0.8)
GluCon4 = new NetCon(upbkgrnd,strAMPAk,0.1,1,0.8)
//netcon = new NetCon(source, target, threshold, delay, weight)

v_init = -79			// from Wickens and Wilson 1998



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