Auditory cortex layer IV network model (Beeman 2013)

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Accession:150678
"... The primary objective of this modeling study was to determine the effects of axonal conduction velocity (often neglected, but significant), as well as synaptic time constants, on the ability of such a network to create and propagate cortical waves. ... The model is also being used to study the interaction between single and two-tone input and normal background activity, and the effects of synaptic depression from thalamic inputs. The simulation scripts have the additional purpose of serving as tutorial examples for the construction of cortical networks with GENESIS. The present model has fostered the development of the G-3 Python network analysis and visualization tools used in this study... It is my hope that this short tutorial and the example simulation scripts can provide a head start for a graduate student or postdoc who is beginning a cortical modeling project. "
Reference:
1 . Beeman D (2013) A modeling study of cortical waves in primary auditory cortex BMC Neuroscience 14(Supl 1):P23
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Auditory cortex;
Cell Type(s): Neocortex V1 pyramidal corticothalamic cell; Neocortex V1 basket intratelencephalic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Tutorial/Teaching;
Implementer(s): Beeman, Dave;
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic cell; Neocortex V1 basket intratelencephalic cell;
  
// bask.p - Cell parameter file for fast spiking basket cell based on FScell06

//	Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees 
// readcell options start with a '*'
// The format for each compartment parameter line is :
//name	parent	r	theta	phi	d	ch	dens ...
//in polar mode, and in cartesian mode :
//name	parent	x	y	z	d	ch	dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//		Coordinate mode
*relative
*cartesian
*asymmetric

//		Specifying constants  -- SI units
*set_compt_param	RM	0.7
*set_compt_param	RA	0.7
*set_compt_param	CM	0.015
*set_compt_param     EREST_ACT	-0.065

// reorient this along -z axis if I want dendrite to point down instead of up

soma  none   0  0  40  40  Na_bask 1000  Kdr_bask 500  GABA_bask 1.0 spike 0.0
dend  soma  0  0  200   2  AMPA_bask 1.0  AMPA_bask_drive 1.0

Beeman D (2013) A modeling study of cortical waves in primary auditory cortex BMC Neuroscience 14(Supl 1):P23

References and models cited by this paper

References and models that cite this paper

Cornelis H, Coop AD, Bower JM (2012) A federated design for a neurobiological simulation engine: the CBI federated software architecture. PLoS One 7:e28956 [PubMed]

Rodriguez AL, Cornelis H, Beeman D, Bower JM (2012) Multiscale modeling with GENESIS 3, using the G-shell and Python BMC Neuroscience 13(Supl 1):P176

(2 refs)