Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Calcium influx during striatal upstates (Evans et al. 2013)
Download zip file
Help downloading and running models
"... To investigate the mechanisms that underlie the relationship between calcium and AP timing, we have developed a realistic biophysical model of a medium spiny neuron (MSN). ... Using this model, we found that either the slow inactivation of dendritic sodium channels (NaSI) or the calcium inactivation of voltage-gated calcium channels (CDI) can cause high calcium corresponding to early APs and lower calcium corresponding to later APs. We found that only CDI can account for the experimental observation that sensitivity to AP timing is dependent on NMDA receptors. Additional simulations demonstrated a mechanism by which MSNs can dynamically modulate their sensitivity to AP timing and show that sensitivity to specifically timed pre- and postsynaptic pairings (as in spike timing-dependent plasticity protocols) is altered by the timing of the pairing within the upstate. …"
Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Neostriatum medium spiny direct pathway GABA cell;
I L high threshold;
I A, slow;
Evans, Rebekah [Rebekah.Evans at nih.gov];
for information about:
Neostriatum medium spiny direct pathway GABA cell
I L high threshold
I A, slow
File not selected
<- Select file from this column.
Loading data, please wait...