Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)

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Accession:151282
" ... We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of Ih. Our model demonstrated that modulation of pyramidal and basket Ih allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal Ih also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via Ih’s ability to set pyramidal excitability. ..."
Reference:
1 . Neymotin SA, Hilscher MM, Moulin TC, Skolnick Y, Lazarewicz MT, Lytton WW (2013) Ih Tunes Theta/Gamma Oscillations and Cross-Frequency Coupling In an In Silico CA3 Model PLoS ONE 8(10):e76285 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s): I Na,t; I A; I K; I K,leak; I h; I K,Ca; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Glutamate;
Gene(s): HCN1; HCN2;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Brain Rhythms; Conductance distributions; Multiscale;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; GabaA; AMPA; NMDA; Glutamate; I Na,t; I A; I K; I K,leak; I h; I K,Ca; I Sodium; I Potassium; Gaba; Glutamate;
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ca3ihdemo
readme.txt
CA3ih.mod
CA3ika.mod
CA3ikdr.mod
CA3ina.mod
caolmw.mod *
HCN1.mod
icaolmw.mod *
iholmw.mod
ihstatic.mod
kcaolmw.mod *
kdrbwb.mod *
misc.mod *
MyExp2SynBB.mod *
MyExp2SynNMDABB.mod *
nafbwb.mod *
stats.mod *
vecst.mod *
aux_fun.inc *
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
geom.py
grvec.hoc *
init.hoc
labels.hoc *
local.hoc *
misc.h *
network.py
nqs.hoc *
nrnoc.hoc *
params.py
pyinit.py *
pywrap.hoc
run.py
sim.py
simctrl.hoc *
stats.hoc *
syncode.hoc *
xgetargs.hoc *
                            
// $Id: default.hoc,v 1.5 2003/07/08 16:16:52 billl Exp $
/* This file contains various global defaults for hoc

** Users should not edit nrnoc.hoc or default.hoc.  Any local 
changes to these files should be made in local.hoc.
----------------------------------------------------------------*/

/*------------------------------------------------------------
Object defaults
------------------------------------------------------------*/

/*** Define a "nil" object ***/
objectvar nil

/*------------------------------------------------------------
String defaults
------------------------------------------------------------*/

/*** "Section" is used if errors are found in the initializiations ***/
strdef section

/*** Misc defines used by graphic routines ***/
temp_string_ = "t"
tempvar = 0

/*------------------------------------------------------------
Simulation defaults
------------------------------------------------------------*/

                        /* To be consistent w/the nmodl values */
FARADAY = 96520.        /* Hoc default = 96484.56 */
PI      = 3.14159       /* Hoc default = 3.1415927 */

                        /* 0=off, 1=on */
print_flag  = 0         /* Write to output file */
graph_flag  = 1         /* Plot output */
iv_flag     = 1         /* Using Interviews plotting */
batch_flag  = 0         /* Using batch_run() */
compress_flag = 0       /* Compress output file when saved */
stoprun     = 0         /* 0=running, 1=stopped */
iv_loaded   = 0         /* Load initial iv stuff on once */

init_seed   = 830529
run_seed    = 680612

t           = 0         /* msec */
dt          = .01       /* msec */
tstop       = 100       /* msec */
printStep   = 0.1       /* msec */
plotStep    = 0.1       /* msec */
flushStep   = 0.1       /* msec */
eventStep   = 50        /* Number of nstep's before a doEvent */

secondorder = 0

celsius     = 6.3       /* degC */

v_init      = -70       /* (mV) */
global_ra   = 200       /* (ohm-cm) specific axial resisitivity */

/*** Ion parameters ***/
ca_init     = 50e-6     /* mM */
na_init     = 10        /* mM */
k_init      = 54.4      /* mM */


Neymotin SA, Hilscher MM, Moulin TC, Skolnick Y, Lazarewicz MT, Lytton WW (2013) Ih Tunes Theta/Gamma Oscillations and Cross-Frequency Coupling In an In Silico CA3 Model PLoS ONE 8(10):e76285[PubMed]

References and models cited by this paper

References and models that cite this paper

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