Sympathetic Preganglionic Neurone (Briant et al. 2014)

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Accession:151482
A model of a sympathetic preganglionic neurone of muscle vasoconstrictor-type.
Reference:
1 . Briant LJ, Stalbovskiy AO, Nolan MF, Champneys AR, Pickering AE (2014) Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. J Neurophysiol 112:2756-2778 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord motor neuron; Spinal cord sympathetic preganglionic neuron;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Temporal Pattern Generation; Parameter Fitting; Action Potentials; Parameter sensitivity;
Implementer(s):
Search NeuronDB for information about:  Spinal cord motor neuron; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I_AHP;
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SPN_ModelDB
hoc_code
MATLAB_code
README.txt
borgka.mod
borgkdr.mod
cadifus2.mod
cagk.mod *
cal2.mod *
can2.mod
gap.mod
gapcalcium.mod
kadist.mod *
kahp.mod *
kaprox.mod *
na3.mod
ActivationProtocol_GKA.dat
ActivationProtocol_IA.dat
ActivationProtocol_V.dat
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ClampFiddy_vhalfm.dat
ClampFiddy_ZetaK.dat
ClampFiddy_ZetaM.dat
ClampHundred.dat
ClampHundred_vhalfm.dat
ClampHundred_ZetaK.dat
ClampHundred_ZetaM.dat
CurrentMagnitude_GKA.dat
CurrentMagnitude_IA.dat
CurrentMagnitude_V.dat
EPSCs_Filtered.txt
InactivationProtocol_GKA.dat
InactivationProtocol_IA.dat
InactivationProtocol_V.dat
init.hoc
mosinit.hoc *
                            
load_file("nrngui.hoc")
load_file("init.hoc")

Briant LJ, Stalbovskiy AO, Nolan MF, Champneys AR, Pickering AE (2014) Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. J Neurophysiol 112:2756-2778[PubMed]

References and models cited by this paper

References and models that cite this paper

Abbott SB, Stornetta RL, Socolovsky CS, West GH, Guyenet PG (2009) Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats. J Physiol 587:5613-31 [PubMed]

Barreiro AK, Thilo EL, Shea-Brown E (2012) A-current and type I-type II transition determine collective spiking from common input. J Neurophysiol 108:1631-45 [PubMed]

Belugin S, Mifflin S (2005) Transient voltage-dependent potassium currents are reduced in NTS neurons isolated from renal wrap hypertensive rats. J Neurophysiol 94:3849-59 [PubMed]

Bernard C, Anderson A, Becker A, Poolos NP, Beck H, Johnston D (2004) Acquired dendritic channelopathy in temporal lobe epilepsy. Science 305:532-5 [PubMed]

Bordey A, Feltz P, Trouslard J (1995) Kinetics of A-currents in sympathetic preganglionic neurones and glial cells. Neuroreport 7:37-40 [PubMed]

Carey RM (2013) Resistant hypertension. Hypertension 61:746-50

Carnevale NT, Hines ML (2006) The NEURON Book

Cassell JF, McLachlan EM (1986) The effect of a transient outward current (IA) on synaptic potentials in sympathetic ganglion cells of the guinea-pig. J Physiol 374:273-88 [PubMed]

Connor JA, Stevens CF (1971) Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma. J Physiol 213:31-53 [PubMed]

Czyzyk-Krzeska MF, Trzebski A (1990) Respiratory-related discharge pattern of sympathetic nerve activity in the spontaneously hypertensive rat. J Physiol 426:355-68 [PubMed]

Dembowsky K, Czachurski J, Seller H (1986) Three types of sympathetic preganglionic neurones with different electrophysiological properties are identified by intracellular recordings in the cat. Pflugers Arch 406:112-20 [PubMed]

Dibona GF, Esler M (2010) Translational medicine: the antihypertensive effect of renal denervation American Journal Of Physiology Regulatory integrative and comparative physiology 298:R245-R253

Esler M (2011) The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension. Exp Physiol 96:611-22 [PubMed]

Fairfax ST, Holwerda SW, Credeur DP, Zuidema MY, Medley JH, Dyke PC, Wray DW, Davis MJ, Fadel (2013) The role of α-adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in the forearm of resting man. J Physiol 591:3637-49 [PubMed]

Fisher JP, Paton JF (2012) The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens 26:463-75 [PubMed]

Forehand CJ (1990) Morphology of sympathetic preganglionic neurons in the neonatal rat spinal cord: an intracellular horseradish peroxidase study. J Comp Neurol 298:334-42 [PubMed]

Grassi G (1998) Role of the sympathetic nervous system in human hypertension. J Hypertens 16:1979-87 [PubMed]

Guo W, Jung WE, Marionneau C, Aimond F, Xu H, Yamada KA, Schwarz TL, Demolombe S, Nerbonne JM (2005) Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res 97:1342-50 [PubMed]

Guyenet PG (2006) The sympathetic control of blood pressure. Nat Rev Neurosci 7:335-46 [PubMed]

Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM (2004) ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci 17:7-11 [Journal] [PubMed]

Hoffman DA, Johnston D (1998) Downregulation of transient K+ channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 18:3521-8 [PubMed]

Jerng HH, Pfaffinger PJ, Covarrubias M (2004) Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci 27:343-69 [PubMed]

Jordan J, Heusser K, Brinkmann J, Tank J (2012) Electrical carotid sinus stimulation in treatment resistant arterial hypertension. Auton Neurosci 172:31-6 [PubMed]

Kasparov S, Teschemacher AG (2008) Altered central catecholaminergic transmission and cardiovascular disease. Exp Physiol 93:725-40 [PubMed]

Kullmann DM (2010) Neurological channelopathies. Annu Rev Neurosci 33:151-72

Logan SD, Pickering AE, Gibson IC, Nolan MF, Spanswick D (1996) Electrotonic coupling between rat sympathetic preganglionic neurones in vitro. J Physiol 495 ( Pt 2):491-502 [PubMed]

Marques FZ, Campain AE, Yang YH, Morris BJ (2010) Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension. Hypertension 56:319-24 [PubMed]

McBryde FD, Abdala AP, Hendy EB, Pijacka W, Marvar P, Moraes DJ, Sobotka PA, Paton JF (2013) The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. Nat Commun 4:2395-24 [PubMed]

Migliore M, Cook EP, Jaffe DB, Turner DA, Johnston D (1995) Computer simulations of morphologically reconstructed CA3 hippocampal neurons. J Neurophysiol 73:1157-68 [Journal] [PubMed]

   CA3 Pyramidal Neuron (Migliore et al 1995) [Model]

Migliore M, Hoffman DA, Magee JC, Johnston D (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J Comput Neurosci 7:5-15 [Journal] [PubMed]

   CA1 pyramidal neuron (Migliore et al 1999) [Model]

Miyazaki T, Dun NJ, Kobayashi H, Tosaka T (1996) Voltage-dependent potassium currents of sympathetic preganglionic neurons in neonatal rat spinal cord thin slices. Brain Res 743:1-10 [PubMed]

Moraes DJ, Machado BH, Paton JF (2014) Specific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension. Hypertension 63:1309-18

Morrison SF, Whitehorn D (1984) Enhanced preganglionic sympathetic nerve responses in spontaneously hypertensive rats. Brain Res 296:152-5 [PubMed]

Nilsson H, Ljung B, Sjöblom N, Wallin BG (1985) The influence of the sympathetic impulse pattern on contractile responses of rat mesenteric arteries and veins. Acta Physiol Scand 123:303-9 [PubMed]

OKAMOTO K, AOKI K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27:282-93 [PubMed]

Paton JF (1996) A working heart-brainstem preparation of the mouse. J Neurosci Methods 65:63-8 [PubMed]

Pickering AE, Paton JF (2006) A decerebrate, artificially-perfused in situ preparation of rat: utility for the study of autonomic and nociceptive processing. J Neurosci Methods 155:260-71 [PubMed]

Pickering AE, Spanswick D, Logan SD (1991) Whole-cell recordings from sympathetic preganglionic neurons in rat spinal cord slices. Neurosci Lett 130:237-42 [PubMed]

Robertson WP, Schofield GG (1999) Primary and adaptive changes of A-type K+ currents in sympathetic neurons from hypertensive rats. Am J Physiol 276:R1758-65 [PubMed]

Rush ME, Rinzel J (1995) The potassium A-current, low firing rates and rebound excitation in Hodgkin-Huxley models. Bull Math Biol 57:899-929 [PubMed]

Sadananda P, Drake MJ, Paton JF, Pickering AE (2011) An exploration of the control of micturition using a novel in situ arterially perfused rat preparation. Front Neurosci 5:62-65 [PubMed]

Sah P, McLachlan EM (1995) Membrane properties and synaptic potentials in rat sympathetic preganglionic neurons studied in horizontal spinal cord slices in vitro. J Auton Nerv Syst 53:1-15 [PubMed]

Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD (2009) Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 361:932-4 [PubMed]

Schramm LP, Barton GN (1979) Diminished sympathetic silent period in spontaneously hypertensive rats. Am J Physiol 236:R147-52 [PubMed]

Schramm LP, Chornoboy ES (1982) Sympathetic activity in spontaneously hypertensive rats after spinal transection. Am J Physiol 243:R506-11 [PubMed]

Schramm LP, Gunther HJ, McKenna KE, Barton GB (1979) Sympathetic hyperactivity and hypertension in adult spontaneously hypertensive rats despite early dorsolateral funicular lesions. Brain Res 167:402-7 [PubMed]

Simms AE, Paton JF, Allen AM, Pickering AE (2010) Is augmented central respiratory-sympathetic coupling involved in the generation of hypertension? Respir Physiol Neurobiol 174:89-97 [PubMed]

Simms AE, Paton JF, Pickering AE, Allen AM (2009) Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension? J Physiol 587:597-610 [PubMed]

Singh B, Ogiwara I, Kaneda M, Tokonami N, Mazaki E, Baba K, Matsuda K, Inoue Y, Yamakawa K (2006) A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy. Neurobiol Dis 24:245-53 [PubMed]

Smith JC, Abdala AP, Koizumi H, Rybak IA, Paton JF (2007) Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms. J Neurophysiol 98:3370-87 [PubMed]

Sonner PM, Filosa JA, Stern JE (2008) Diminished A-type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats. J Physiol 586:1605-22 [PubMed]

Spanswick D, Logan SD (1990) Sympathetic preganglionic neurones in neonatal rat spinal cord in vitro: electrophysiological characteristics and the effects of selective excitatory amino acid receptor agonists. Brain Res 525:181-8 [PubMed]

Spanswick D, Renaud LP, Logan SD (1998) Bilaterally evoked monosynaptic EPSPs, NMDA receptors and potentiation in rat sympathetic preganglionic neurones in vitro. J Physiol 509 ( Pt 1):195-209

Stalbovskiy AO, Briant LJ, Paton JF, Pickering AE (2014) Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ. J Physiol 592:2215-36

Sved AF, Ito S, Sved JC (2003) Brainstem mechanisms of hypertension: role of the rostral ventrolateral medulla. Curr Hypertens Rep 5:262-8 [PubMed]

Whyment AD, Coderre E, Wilson JM, Renaud LP, O'Hare E, Spanswick D (2011) Electrophysiological, pharmacological and molecular profile of the transient outward rectifying conductance in rat sympathetic preganglionic neurons in vitro. Neuroscience 178:68-81 [PubMed]

Wilson JM, Coderre E, Renaud LP, Spanswick D (2002) Active and passive membrane properties of rat sympathetic preganglionic neurones innervating the adrenal medulla. J Physiol 545:945-60 [PubMed]

Yoshimura M, Polosa C, Nishi S (1986) Afterhyperpolarization mechanisms in cat sympathetic preganglionic neuron in vitro. J Neurophysiol 55:1234-46 [PubMed]

Yoshimura M, Polosa C, Nishi S (1986) Electrophysiological properties of sympathetic preganglionic neurons in the cat spinal cord in vitro. Pflugers Arch 406:91-8 [PubMed]

Yoshimura M, Polosa C, Nishi S (1987) A transient outward rectification in the cat sympathetic preganglionic neuron. Pflugers Arch 408:207-8 [PubMed]

Zimmerman A, Hochman S (2010) Heterogeneity of membrane properties in sympathetic preganglionic neurons of neonatal mice: evidence of four subpopulations in the intermediolateral nucleus. J Neurophysiol 103:490-8 [PubMed]

(61 refs)