CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)

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Accession:151731
The paper discusses the effects induced by an electric field at power lines frequency.
Reference:
1 . Cavarretta F, Carnevale NT, Tegolo D, Migliore M (2014) Effects of low frequency electric fields on synaptic integration in hippocampal CA1 pyramidal neurons: implications for power line emissions. Front Cell Neurosci 8:310 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Extracellular;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Extracellular Fields;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Migliore, Michele [Michele.Migliore at Yale.edu]; Cavarretta, Francesco [francescocavarretta at hotmail.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I h; Glutamate;
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CavarrettaEtAl2014
readme.html
fzap.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstimm.mod *
xtrau.mod *
anatscale.hoc *
biophys.hoc
calcd.hoc
calcrxcu.hoc
efheader.hoc *
geo5038804.hoc *
init.hoc
interpxyzu.hoc *
mosinit.hoc *
prova.ses
rigc.ses
screenshot.png
setnseg.hoc *
setpointersu.hoc *
synapses.hoc
voltage.ses
zapstimu.hoc
                            
load_file("nrngui.hoc")

load_file("geo5038804.hoc")
numbasal  = 52
numapical = 70
numuser5  = 49

load_file("biophys.hoc")
load_file("synapses.hoc")
load_file("efheader.hoc")



tstop=700

proc init() {

  t=0

  
  finitialize(Vrest)

	forall {
		v = Vrest
		if(ismembrane("nax") || ismembrane("na3")) {
			ena=55
		}
		if(ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {
			ek=-90
		}
		if(ismembrane("hd")) {
			ehd_hd=-30
		}
	}

	finitialize(Vrest)
	fcurrent()

	forall {
		for(x) {
			if(ismembrane("na3") || ismembrane("nax")) {
				e_pas(x)=v(x)+(ina(x)+ik(x))/g_pas(x)
			}
			if(ismembrane("hd")) {
				e_pas(x)=e_pas(x)+i_hd(x)/g_pas(x)
			}
		}
	}

}



load_file("voltage.ses")

objref vp
vp = Graph[1]
vp.exec_menu("Keep Lines")

proc sim() {

  vp.erase_all()
  vp.label(0.8, 0.931495, "no EF", 2, 1, 0, 0, 1)
  vp.label(0.8, 0.878114, "EF", 2, 1, 0, 0, 2)

  vp.brush(2)
  vp.color(1)
  vp.addvar("", "v(0.5)")
  for i = 0, nsyn-1 {
    st[i].seed(114+i)
    nc[i].weight=2e-4
  }
  setstim(100, 500, 0, 0, 40)
  changefield(100, 90, 90)
  run()

  vp.color(2)
  vp.addexpr("", "v(0.5)")
  for i = 0, nsyn-1 {
    st[i].seed(114+i)
    nc[i].weight=2e-4
  }
  setstim(100, 500, 50, 50, 40)
  changefield(100, 90, 90)
  run()
}

xpanel("")
xbutton("run sim", "sim()")
xpanel(200,200)


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