Model of repetitive firing in Grueneberg ganglion olfactory neurons (Liu et al., 2012)

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Accession:151817
This model is constructed based on properties of Na+ and K+ currents observed in whole-cell patch clamp recordings of mouse Grueneberg ganglion neurons in acute slices. Two distinct Na+ conductances representing the TTX-sensitive and TTX-resistant currents and one delayed rectifier K+ currrent are included. By modulating the maximal conductances of Na+ currents, one can reproduce the regular, phasic, and sporadic patterns of repetitive firing found in the patch clamp experiments.
Reference:
1 . Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents. J Neurophysiol 108:1318-34 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory receptor neuron; Grueneberg ganglion neuron;
Channel(s): I K; I K,leak; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Temporal Pattern Generation; Action Potentials; Rebound firing; Recurrent Discharge;
Implementer(s): Liu, Cambrian [camliu at chla.usc.edu];
Search NeuronDB for information about:  Olfactory receptor neuron; I K; I K,leak; I Sodium;
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GG
readme.txt
code_holder.hoc
elvis.ses
elvism10.ses
elvisp10.ses
graphs.hoc
gui_controller.hoc
hvas.ses
iclamp.hoc
init.hoc
kchannels.ses
leak.ses
mosinit.hoc *
runner.hoc
soma.hoc
                            
This is the readme for the model associated with the paper:

Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS (2012)
Electrophysiological characterization of Grueneberg ganglion olfactory
neurons: spontaneous firing, sodium conductance, and
hyperpolarization-activated currents. J Neurophysiol 108:1318-34

This is the NEURON code that was used by the paper authors.
NEURON is available for free at http://www.neuron.yale.edu

This model does not contain any mod files so you can start simulations
by double clicking the init.hoc file (mswin), dragging and dropping
the init.hoc file on nrngui (mac) or typing "nrngui init.hoc" on the
command line (unix/linux).


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