Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)

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Accession:151825
We used a combined experimental and numerical parameter peeling procedure was implemented to optimize a detailed ionic mechanism for the generation and propagation of dendritic spikes in neocortical L5 pyramidal neurons. Run the cc_run.hoc to get a demo for dendritic calcium spike generated by coincidence of a back-propagating AP and distal synaptic input.
Reference:
1 . Almog M, Korngreen A (2014) A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons J Neurosci 34(1):182-196
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex layer 5-6 pyramidal cell;
Channel(s): I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com];
Search NeuronDB for information about:  Neocortex layer 5-6 pyramidal cell; I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump;
This is the readme for the model associated with the paper:

Almog M, Korngreen A (2014) A Quantitative Description of Dendritic
Conductances and Its Application to Dendritic Excitation in Layer 5
Pyramidal Neurons J Neurosci 34(1):182-196

This is the NEURON code the authors used.  NEURON is freely available
at http://www.neuron.yale.edu

To run demo compile the mod files (mknrndll (mswin and mac) or
nrnivmodl (linux/unix) start cc_run.hoc with the method appropriate to
your platform (double click (mswin),drag and drop onto nrngui icon
(mac) or "nrngui cc_run.hoc" on the command line (unix/linux).