Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP)

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Accession:152966
A mathematical model of the membrane action potential of the mammalian ventricular cell introduced in Luo, Rudy 1991 and used in Wang et al 2006 is made available here in XPP. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. ... The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics. See papers for more and details.
References:
1 . Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ Res 74:1097-113 [PubMed]
2 . Wang YJ, Sung RJ, Lin MW, Wu SN (2006) Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. J Membr Biol 213:175-85 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I Sodium; I Calcium; I Potassium; ATP-senstive potassium current; I_HERG; Na/Ca exchanger; I_Na,Ca; I_SERCA; KCNQ1; I_Ks; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Action Potentials; Calcium dynamics; Triggered activity;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
Search NeuronDB for information about:  I Sodium; I Calcium; I Potassium; ATP-senstive potassium current; I_HERG; Na/Ca exchanger; I_Na,Ca; I_SERCA; KCNQ1; I_Ks; Ca pump;
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LRdynamic
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