Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells (Lee et al. 2014)

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Accession:153280
This detailed microcircuit model explores the network level effects of sublayer specific connectivity in the mouse CA1. The differences in strengths and numbers of synapses between PV+ basket cells and either superficial sublayer or deep sublayer pyramidal cells enables a routing of inhibition from superficial to deep pyramidal cells. At the network level of this model, the effects become quite prominent when one compares the effect on firing rates when either the deep or superficial pyramidal cells receive a selective increase in excitation.
Reference:
1 . Lee SH, Marchionni I, Bezaire M, Varga C, Danielson N, Lovett-Barron M, Losonczy A, Soltesz I (2014) Parvalbumin-Positive Basket Cells Differentiate among Hippocampal Pyramidal Cells Neuron 82(5):1129-44 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell;
Channel(s): I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Connectivity matrix; Laminar Connectivity;
Implementer(s): Bezaire, Marianne [mariannejcase at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; Glutamate; I Sodium; I Calcium; I Potassium;
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'superdeep' model code repository
Written by Marianne Bezaire, marianne.bezaire@gmail.com, www.mariannebezaire.com
Last updated on May 15, 2014

This code is associated with the publication:
Lee S, Marchionni I, Bezaire MJ, Varga C, Danielson N, Lovett-Barron M, Losonczy A, Soltesz I.
GABAergic Basket Cells Differentiate Among Hippocampal Pyramidal Cells.
Neuron, 2014. In press.
http://www.cell.com/neuron/abstract/S0896-6273%2814%2900336-5

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To run the full model, at the command line enter:
$ cd superdeep
$ nrnivmodl # or mknrndll for windows
$ nrniv superdeep.hoc

To run the full model on a supercomputer, see the example jobscript files
in the jobscript folder. Depending on the supercomputer, you may need to
submit a jobscript in one of the following formats:

cd superdeep
$ qsub jobscripts/Santa_01.sh

OR

cd superdeep
$ sbatch jobscripts/Santa_01.sh

Check your supercomputer's User Guide for further assistance.

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Latest versions of this code are available online at:
ModelDB: http://senselab.med.yale.edu/ModelDB/ShowModel.asp?model=153280
Open Source Brain: http://www.opensourcebrain.org/projects/nc_superdeep

This code can be used with the SimTracker tool:
http://senselab.med.yale.edu/SimToolDB/ShowTool.asp?Tool=153281

If you do not want to run this code, but want to analyze the results obtained by
running this code, the results are currently available upon request by
emailing marianne.bezaire@gmail.com

If you want to view a graphical description of the model network built
by this code, please see: 
http://www.ivansolteszlab.org/models/superdeep/graphicalmodel.html

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For more information about this code, see:
- ModelDB Quick Start Guide.pdf (included with model code)
- SimTracker NEURON Template User Guide.pdf (included with model code)
- Lab website: http://www.ivansolteszlab.org/models/superdeep.html

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