Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells (Lee et al. 2014)

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Accession:153280
This detailed microcircuit model explores the network level effects of sublayer specific connectivity in the mouse CA1. The differences in strengths and numbers of synapses between PV+ basket cells and either superficial sublayer or deep sublayer pyramidal cells enables a routing of inhibition from superficial to deep pyramidal cells. At the network level of this model, the effects become quite prominent when one compares the effect on firing rates when either the deep or superficial pyramidal cells receive a selective increase in excitation.
Reference:
1 . Lee SH, Marchionni I, Bezaire M, Varga C, Danielson N, Lovett-Barron M, Losonczy A, Soltesz I (2014) Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron 82:1129-44 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell;
Channel(s): I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Connectivity matrix; Laminar Connectivity;
Implementer(s): Bezaire, Marianne [mariannejcase at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; Glutamate; I Sodium; I Calcium; I Potassium;
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ch_CavL.mod
ch_CavLZ.mod
ch_CavN.mod
ch_CavT.mod
ch_HCNp.mod
ch_KCaS.mod
ch_Kdrfast.mod
ch_Kdrp.mod
ch_Kdrslow.mod
ch_KvA.mod
ch_KvAdistp.mod
ch_KvAproxp.mod
ch_KvCaB.mod
ch_leak.mod
ch_Navp.mod
ch_NavPVBC.mod
iconc_Ca.mod
iconc_CaZ.mod
MyExp2Sid.mod
MyExp2Sidnw.mod *
mynetstim.mod *
repeatconn.mod
hg_diff.out *
hg_status.out *
ModelDB Quick Start Guide.pdf
modelview.hoc
superdeep.hoc
vercomment.txt *
version.txt *
                            
strdef RunName
RunName="ModelView"
strdef UID
UID="0000000-D056-4AA0-90B7-64BA964A95B"
strdef Stimulation
Stimulation="spontaneous"
strdef Connectivity
Connectivity="try_all_repeatstim"
Scale=1
SimDuration=2
RandomSeeds=1500000
strdef Positioning
Positioning=""
PrintVoltage=0
PrintTerminal=0
PrintConnDetails=0
PrintCellPositions=0
PrintConnSummary=0
TransverseLength=1000
LongitudinalLength=6000
strdef LayerHeights
LayerHeights="4;100;50;200;100;"
SpatialResolution=100
ConnData=193
SynData=116
NumData=110
TemporalResolution=0.05
NumTraces=40
FracTraces=100
DegreeStim=1.81
Onint=0.215
Offint=0.125
PercentCellDeath=0
PercentAxonSprouting=0
RipStim=0.38
CatFlag=1
RandomSeedsConn=1500000
RandomSeedsStim=1500000
AxConVel=0
StepBy=100
JobHours=12
EstWriteTime=660
{load_file("./superdeep.hoc")}

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