Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
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param_struct.h
per_ext.h
per_struct.h
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profile.h
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seg_defs.h
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shell.h
shell_defs.h
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shell_func_ext.h
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shell_struct.h
sim.h
sim_defs.h
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sim_struct.h
sim_version.h
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simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
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SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
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tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/*
** $Id: buf_struct.h,v 1.1.1.1 2005/06/14 04:38:28 svitak Exp $
** $Log: buf_struct.h,v $
** Revision 1.1.1.1  2005/06/14 04:38:28  svitak
** Import from snapshot of CalTech CVS tree of June 8, 2005
**
** Revision 1.1  1992/12/11 19:02:36  dhb
** Initial revision
**
*/

#include "struct_defs.h"

/*
*******************************
**         EVENT             **
*******************************
*/
struct variable_type {
	float 	value;
};

/*
*******************************
**         BUFFER            **
*******************************
*/

struct random_type {
    BUFFER_TYPE
    float	state;
    float	rate;
    float	max_amp;
    float	min_amp;
    short	reset;
    float	reset_value;
};

struct playback_type {
    BUFFER_TYPE
    float	state;
};

struct periodic_type {
    BUFFER_TYPE
    float	state;
    float	stime;
    float	scale;
    short	mode;
};

struct spike_type {
    BUFFER_TYPE
    float	state;
    float 	thresh;
    float 	abs_refract;
    float 	output_amp;
};

struct state_type {
    BUFFER_TYPE
    float	state;
};

struct graded_type {
    BUFFER_TYPE
    float	state;
    float 	baseline;
    float 	scale;
    float 	rectify;
};

struct sigmoid_type {
    BUFFER_TYPE
    float	input;
    float	state;
    float 	gain;
    float 	amplitude;
    float 	thresh;
};

struct linear_type {
    BUFFER_TYPE
    float	state;
    float 	gain;
    float 	thresh;
};

struct inject_type {
    BUFFER_TYPE
    float 	inject;
};

/* New buffer type for use with integration methods (BPG 15-5-91) */
struct passive_type {
    BUFFER_TYPE
};

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