Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
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absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
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diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
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netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
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olf_struct.h
out_defs.h
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profile.h
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sim.h
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sim_version.h
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SynGS_struct.h
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tools.h
user_ext.h
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user_struct.h
                            
#define concpool_CONCEN 0
#define concpool_STOREINFLUX 4
#define concpool_STOREOUTFLUX 5
#define concpool_BUFFER 10
#define concpool_HILLPUMP 14
#define difshell_INFLUX 0
#define difshell_OUTFLUX 1
#define difshell_FINFLUX 2
#define difshell_FOUTFLUX 3
#define difshell_STOREINFLUX 4
#define difshell_STOREOUTFLUX 5
#define difshell_DIFF_DOWN 6
#define difshell_DIFF_UP 7
#define difshell_BUFFER 10
#define difshell_TAUPUMP 11
#define difshell_EQTAUPUMP 12
#define difshell_MMPUMP 13
#define difshell_HILLPUMP 14
#define taupump_VOLTAGE 0
#define mmpump_CONCEN 0
#define mmpump_MMKD 1
#define hillpump_MMKD 1
#define fixbuffer_CONCEN 0
#define difbuffer_CONCEN 0
#define difbuffer_BDIFF_DOWN 1
#define difbuffer_DIFF_DOWN 1
#define difbuffer_BDIFF_UP 2
#define difbuffer_DIFF_UP 2
#define dif2buffer_CONCEN 0
#define dif2buffer_BDIFF_DOWN 1
#define dif2buffer_BDIFF_UP 2
#define fura2_CONCEN 0

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