Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
/
LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/*********************************************************************

** This library uses the netcdf - version 3.4 which is
** Copyright 1993-1997 University Corporation for Atmospheric Research/Unidata

** The netcdf library is provided as per the terms of the
** UCAR/Unidata license.

** See interface/netcdf-3.4/copyright.html for the full notice.

********************************************************************/

/* $Id: diskio_struct.h,v 1.1.1.1 2005/06/14 04:38:29 svitak Exp $ */
/*
 * $Log: diskio_struct.h,v $
 * Revision 1.1.1.1  2005/06/14 04:38:29  svitak
 * Import from snapshot of CalTech CVS tree of June 8, 2005
 *
 * Revision 1.7  2000/06/12 05:07:01  mhucka
 * Removed nested comments; added NOTREACHED comments where appropriate.
 *
 * Revision 1.6  1999/10/16 21:52:46  mhucka
 * Merged Upi's changes for supporting netCDF 3.4.  The changes in most files
 * only involve the copyright notice.  I also fixed up the comments slightly
 * to reflect the location of the actual netCDF copyright file.
 *
 * Revision 1.5  1999/10/16 21:23:47  mhucka
 * Venkat had a version of the diskio code in his home directory that he
 * appears to have been working on, and that did not make it into the
 * source tree that I had originally used as the starting point of my
 * GENESIS 2.2.2 DR reorganization effort.  In order to merge Venkat's
 * changes into the distribution, I'm reverting to his version, then will
 * update his version to incorporate recent changes by Upi for netCDF 3.4.
 *
 * Revision 1.3  1998/01/13 20:51:13  venkat
 * Addition of members to the various structures to support FMT1
 *
 * Revision 1.2  1997/07/26 00:12:00  venkat
 * Added
 * */

#include "struct_defs.h"



/** 
 	###############################
	 The object structures 
	###############################
**/

struct Gen_Diskio_Type {
 ELEMENT_TYPE
 /* 
    ###########
	Fields to be shown with a showfield 
    ###########
 */
 
 /* Name of file to which interfaced */
 char *filename;

 /* Format of the file - FMT1, Netcdf etc., */
 char *fileformat;

 /* States of the file */
 short is_open;
 short is_writable;
 char accessmode;

 /* Hidden Abstract interface members */
 char *adi; 
 char *coordi;
 /* Hidden count of time step */
 long start_time_index[1];
 /* Hidden cache of time value */
 float currenttime;

 /* Backwards compatibility (with disk_out/disk_in) fields */

 float **val; /* Frame of values to be read from file on disk every time step*/
 char **autoSAVEavi; /* The frame of variable interface handles */ 
 int nx; 	    /* The number of such frames read every time step - Is 1 for FMT1 and
		     the same holds for diskio as well at this point */
 int ny;	    /* Number of values in a single frame = number of autoSAVE variable children*/	

 short valsallocated; /* flag- Are the frames allocated ? */
 short append; /* Should data be appended after resetting */

 char **autoSAVEamdi; /* Frame of 3-D Pos metadata interface handles */

 /**** The same fields as in disk_in *******/

 /* These hold the 3-D coords of the src element*/
 struct interpol_struct *xpts;
 struct interpol_struct *ypts;
 struct interpol_struct *zpts;

 float start_time;
 float dt;
 float time_offset;
 int datatype;
 int header_size;
 short leave_open; 
 short flush;

 /* Flag that helps disallow additions/deletions of messages after a RESET */
 short already_reset;
};

struct Gen_Variable_Type {
 ELEMENT_TYPE

 /* The number of values stored */
 int size;
 /* The datatype of the values stored */
 char *datatype;
 /* A specific value as string */
 char *value;
 
 /* input and output fields for messages and basic simulation functionality */
 /* Made hidden for FMT1 since variables cannot receive and send messages
    directly
 */
 double input;
 double output;

 /* Hidden Abstract interface members */
 char *avi;
 char *coordi;
 /* Hidden count of time step */
 long start_time_index[1];
};

struct Gen_Metadata_Type {
 ELEMENT_TYPE

 /* The number of attrib vals */
 int size;
 /* The datatype of attrib vals */
 char *datatype; 
 /* A value as string */
 char *value;

 /* Hidden Abstract interface member */
 char *amdi;
};

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