Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/*
 *
 * FILE: fac_ext.h
 *
 *      Externally-required definitions for the fac library.
 *
 *
 * AUTHOR: Mike Vanier
 *
 */

/*
 *
 * Copyright (c) 1999 Michael Christopher Vanier
 * All rights reserved.
 *
 * Permission is hereby granted, without written agreement and without license
 * or royalty fees, to use, copy, modify, and distribute this software and its
 * documentation for any purpose, provided that the above copyright notice and
 * the following two paragraphs appear in all copies of this software.
 *
 * In no event shall Michael Christopher Vanier (hereinafter referred to as
 * "the author") or the Genesis Developer's Group be liable to any party for
 * direct, indirect, special, incidental, or consequential damages arising out
 * of the use of this software and its documentation, even if the author
 * and/or the Genesis Developer's Group have been advised of the possibility
 * of such damage.
 *
 * The author and the Genesis Developer's Group specifically disclaim any
 * warranties, including, but not limited to, the implied warranties of
 * merchantability and fitness for a particular purpose.  The software
 * provided hereunder is on an "as is" basis, and the author and the Genesis
 * Developer's Group have no obligation to provide maintenance, support,
 * updates, enhancements, or modifications.
 *  
 */

#ifndef FAC_EXT_H
#define FAC_EXT_H

#include <stdio.h>
#include <stdlib.h>
#include <string.h>

#include "sim_ext.h"
#include "shell_func_ext.h"
#include "fac_debug.h"
#include "fac_defs.h"
#include "newconn_struct.h"
#include "fac_struct.h"
#include "synaptic_event.h"
#include "printoptusage.h"

/*
 * External functions used by this library.  ANSI-style declarations
 * don't seem to work due to type conversion weirdnesses.  Oh well.
 */

/*
extern int       Error();
extern int       Warning();
extern int       InvalidAction();
extern int       CallEventAction();
extern char     *Pathname();
extern float     ran1();
extern int       initopt();
extern int       G_getopt();
extern char*     G_optopt;
*/
extern int       Cellreader_read_channel();
extern void      RemovePendingSynapticEvents();
extern void      RemapMsgData();
extern void      SaveSynapticEvents();
extern int       RestoreSynapticEvents();
extern int       SaveSizeSynapticEvents();
extern int       Synchan_SET();
extern int       Synchan_SHOW();


#endif /* FAC_EXT_H */

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