Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
/
LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/* Version EDS22h 99/03/10, Erik De Schutter, Caltech & BBF-UIA 4/92-3/99 */

/*
** $Id: hines_defs.h,v 1.2 2006/01/09 16:28:50 svitak Exp $
**
** $Log: hines_defs.h,v $
** Revision 1.2  2006/01/09 16:28:50  svitak
** Increases in size of storage for comparment names. These can be very long
** when cvapp converts from Neurolucida format.
**
** Revision 1.1.1.1  2005/06/14 04:38:32  svitak
** Import from snapshot of CalTech CVS tree of June 8, 2005
**
** Revision 1.4  2000/07/03 18:22:25  mhucka
** This file does not need to redefine FARADAY, GAS_CONSTANT and ZERO_CELSIUS.
**
** Revision 1.3  1999/10/17 21:39:37  mhucka
** New version of Hines code from Erik De Schutter, dated 30 March 1999
** and including an update to hines.c from Erik from June 1999.  This version
** does not include changes to support Red Hat 6.0 and the Cray T3E, which
** will need to be incorporated in a separate revision update.
**
 * EDS22h revison: EDS BBF-UIA 99/03/10-99/03/10
 * Improved concpool code
 *
 * EDS22d revison: EDS BBF-UIA 98/05/04-98/05/05
 * Made instant gates work
 *
 * EDS22c revison: EDS BBF-UIA 97/11/28-98/03/12
 * Made symmetric compartments work
 *
 * EDS22b revison: EDS BBF-UIA 97/11/14-97/11/19
 * Added hillpump and pool defs
 *
** Revision 1.1  1997/05/28 23:11:50  dhb
** Initial revision
**
*/

/* action numbers */
#define DUPLICATE 202
#define HPROCESS 250
#define HSEVENT  251
#define HPUT 300
#define HGET 301
#define HRESTORE 302
#define HSAVE 303
#define HCHANGE 304

#define ERR -1
#define NOT -2

/* array sizes */
#define NAMELEN 1024
#define MAXELMS 4
#define MAXTABC 40	/* max number of conc conductance rate factor tables */
#define MAXTABV 80	/* max number of all conductance rate factor tables */
#define SYNSIZE 4
#define MAXSYN 60	/* max number of synaptic equation tables */
#define MAXNAMES 10000 /* max number of different elm names */
#define MAXPROTOS 100
#define MAXPROTOCOMPS 1000
#define MAXCOMPS 10000

/* msg numbers */
#define CHANNEL 0
#define CHANNEL1 1
#define CHANNEL2 2
#define RAXIAL 1
#define AXIAL 2
#define INJECT 3
#define CONNECTCROSS 5
#define EREST   6
#define INPUT 0
#define THRESH 1
#define SPIKE -1
#define VOLTAGE 0
#define CONCEN 1
#define CONCEN1 1
#define CONCEN2 2
#define DOMAINCONC 3
#define EK 4
#define I_Ca 0
#define fI_Ca 1
#define BASE 4
#define CIN 0
#define COUT 1
#define GVOLTAGE 3
#define PERMEABILITY 4
#define ADD_GBAR 5
#define ACTIVATION 1
#define INFLUX 0
#define OUTFLUX 1
#define FINFLUX 2
#define FOUTFLUX 3
#define STOREINFLUX 4
#define STOREOUTFLUX 5
#define DIFF_DOWN 6
#define DIFF_UP 7
#define BUFFER 10
#define TAUPUMP 11
#define EQTAUPUMP 12
#define MMPUMP 13
#define HILLPUMP 14
#define BCONCEN 0
#define BDIFF_DOWN 1
#define BDIFF_UP 2

/* hget_msg_elm codes */
#define MONE -1
#define NOERR -2

/* float comparisons */
#define TINY 1.0e-6
#define VTINY 1.0e-10
#define MTINY 1.0e-12
#define UTINY 1.0e-30

/* funcs codes */
#define FORWARD_ELIM 0
#define BACKWARD_ELIM 0
#define SET_DIAG 1
#define SKIP_DIAG 2
#define FASTSIBARRAY_ELIM 3
#define COPY_ARRAY 4
#define SIBARRAY_ELIM 5
#define CALC_RESULTS 6
#define FINISH 7

/* childtypes codes */
#define COMPT_T 1
#define NEUTRAL_T 10
#define SPIKEGEN_T 11
#define ELMMPUMP_T 15
#define ANYCHAN_T 2
#define TABCHAN_T 20
#define TAB2CHAN_T 21
#define TABCURR_T 26
#define TABFLUX_T 27
#define SYNCHAN_T 3
#define CHANC2_T 30
#define CHANC3_T 31
#define SYNCHANC_T 32
#define MGBLOCK_T 33
#define NERNST_T 40
#define GHK_T 41
#define TABGHK_T 42
#define CACONCEN_T 50
#define TAUPUMP_T 51
#define MMPUMP_T 52
#define HILLPUMP_T 53
#define FURA2_T 54
#define POOLBUFF_T 55
#define POOL_T 59
#define FIXBUFF_T 60
#define BUFSHELL_T 61
#define BUFSLAB_T 62
#define BUFUSER_T 63
#define BUF2SHELL_T 66
#define BUF2SLAB_T 67
#define BUF2USER_T 68
#define DIFSHELL_T 71
#define DIFSLAB_T 72
#define DIFUSER_T 73
/* childlink codes */
#define NODIFF 0
#define DIFFDOWN 1
#define DIFFUP 2
#define DIFFBOTH 3
#define FLUXOFFSET 10
/* childpos codes */
#define ANYPOOL  -2000
#define ANYSUBSHELL  -1000
#define SUBMEMBRANE  -1
#define SUPRAMEMBRANE 1
#define ANYSUPRASHELL 1000

/* op codes */
#define TABCURR_OP 0
#define POWER_OP 10
#define COMPT_OP 100
#define FCOMPT_OP 101
#define LCOMPT_OP 102
#define SPIKE_OP 200
#define ELMMPUMP_OP 500
#define CONC_VAL_OP 1000
#define NERNST_OP 2000
#define GHK_OP 2010
#define CHAN_OP 3000
#define CHAN_EK_OP 3001
#define SAME_GHK_OP 3002
#define DO_TABGHK_OP 3003
#define ADD_CURR_OP 3200
#define FLUX_OP 3300
#define SCALE_FLUX_OP 3301
#define STORE_ALL_OP 3500
#define STORE_ALLI_OP 3501
#define STORE_ALLC_OP 3502
#define IPOL1V_OP 4001
#define IPOL1C_OP 4002
#define IPOL2V_OP 4003
#define IPOL2C_OP 4004
#define SYN2_OP 4100
#define SYN3_OP 4101
#define MGBLOCK_OP 4200
#define NEWVOLT_OP 5100
#define NEWCONC1_OP 5110
#define NEWCONC2_OP 5111
#define DOMAIN_OP 5112
#define CONC_OP 10100
#define FCONC_OP 10101
#define LCONC_OP 10102
#define FLUXCONC_OP 10103
#define CACONC_OP 10200
#define LCACONC_OP 10202
#define TAUPUMP_OP 11000
#define CTAUPUMP_OP 11001
#define MMPUMP_OP 11010
#define HILLPUMP_OP 11011
#define PHILLPUMP_OP 11012
#define BUFFER_OP 12000
#define POOL_OP 12100

/* iinfo codes */
#define INJECT_OP 1
#define BASE_OP 2
#define THRESH_OP 3

/* readflag codes */
#define HPROTO_T -1		/* prototype hsolve created by readhines */
#define HSETUP_T  0		/* standard initialization by SETUP */
#define HREAD_T   1		/* created and initialized by readhines */
#define HDUPLICATE_T 2	/* copied and initialized by DUPLICATE */


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